FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel)

DRUG4 trials

Sponsors

The Netherlands Cancer Institute, Guangdong Provincial People's Hospital, Massachusetts General Hospital, McGill University Health Centre/Research Institute of the McGill University Health Centre

Conditions

Adenocarcinoma Gastroesophageal JunctionAdenocarcinoma StomachGastric Cancer Stage IIIGastroesophageal AdenocarcinomaResectable MMR-deficient Solid TumorsResectable MMR-proficient Solid Tumors

Phase 2

Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations

RecruitingNCT06279130

The Netherlands Cancer InstituteResectable MMR-deficient Solid Tumors, Resectable MMR-proficient Solid Tumors

Start: 2024-01-29End: 2034-01-29Target: 133Updated: 2026-03-05

A Randomized Controlled Study of Serplulimab Combined With Chemotherapy for Locally Advanced Gastric Adenocarcinoma

Active, not recruitingNCT07257575

Guangdong Provincial People's HospitalGastric Cancer Stage III

Start: 2025-01-05End: 2031-06-30Target: 138Updated: 2025-12-02

Zimberelimab + Domvanalimab in Gastroesophageal Adenocarcinoma

WithdrawnNCT07283848

Massachusetts General HospitalAdenocarcinoma Gastroesophageal Junction, Adenocarcinoma Stomach

Start: 2026-02-01End: 2029-12-01Updated: 2025-12-26

RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial

Not yet recruitingNCT07625930

McGill University Health Centre/Research Institute of the McGill University Health CentreGastroesophageal Adenocarcinoma

Start: 2027-01-01End: 2031-04-01Target: 184Updated: 2026-07-10

Related Papers

Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial

Nature Medicine2024-09-1642 citations