FLAG

DRUG3 trials

Sponsors

National Cancer Institute (NCI)

Conditions

Acute LeukemiaHodgkin's LymphomaHodgkins LymphomaLeukemiaMDSMultiple MyelomaMyelodysplastic SyndromeMyelodysplastic Syndromes

Phase 1

Chemotherapy and Unrelated Donor Stem Cell Transplantation for Patients With Cancers of the Blood and Immune System

CompletedNCT00520130

National Cancer Institute (NCI)Acute Leukemia, Hodgkin's Lymphoma, Multiple Myeloma +2

Start: 2007-10-30End: 2018-12-31Updated: 2019-03-05

Pilot Trial of Targeted Immune-Depleting Chemotherapy and Reduced-Intensity Matched Unrelated Double Cord Blood Transplant for the Treatment of Leukemias, Lymphomas, and Pre-Malignant Blood Disorders

TerminatedNCT00973804

National Cancer Institute (NCI)Hodgkins Lymphoma, Leukemia, MDS +2

Start: 2009-08-25End: 2013-05-20Updated: 2019-12-17

Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

CompletedNCT02356159

National Cancer Institute (NCI)Acute Leukemia, Hodgkin's Lymphoma, Multiple Myeloma +2

Start: 2015-09-24End: 2025-03-25Updated: 2025-09-30

Related Papers

Impact of fludarabine exposure on overall survival in patients receiving fludarabine/cyclophosphamide reduced intensity conditioning hematopoietic cell transplantation for hematologic malignancies

Blood2025-11-03

Phase 1/2 study of high-dose palifermin for GVHD prophylaxis in patients undergoing HLA-matched unrelated donor HCT

Blood2025-05-071 citations

High-dose alemtuzumab and cyclosporine vs tacrolimus, methotrexate, and sirolimus for chronic graft-versus-host disease prevention

Blood Advances2024-04-269 citations

Preconditioning Single High-Dose Palifermin Alters the Posttransplant Inflammatory Cytokine Profile

Blood2023-11-02

A Phase 1 Single Dose Escalation Study of Palifermin Administered Pre-Transplant Conditioning in Subjects Undergoing Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation

Blood2020-11-052 citations

Salivary Zymogen Granule Protein 16B Drops at Onset of Chronic Graft-Versus-Host Disease: A Possible Salivary Biomarker for Oral Chronic Graft-Versus-Host Disease

Biology of Blood and Marrow Transplantation2019-01-31

Human Th17 activity profile in oral chronic Graft-versus-Host Disease

The Journal of Immunology2017-05-01

Th17 Recruitment and Interferon Pathway Activation in Oral Chronic Graft-Versus-Host Disease Tissues

Biology of Blood and Marrow Transplantation2016-02-18

Upregulation of Interferon-Inducible and Damage Response Receptors in Chronic Graft-Versus-Host Disease

Blood2015-12-033 citations

Alemtuzumab-Cyclosporine Versus Tacrolimus-Methotrexate-Sirolimus for Graft-Versus-Host Disease Prophylaxis in Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors: Final Results of a Randomized Trial

Blood2015-12-032 citations