Fibrinogen concentrate

DRUG15 trials

Sponsors

University of Edinburgh, University of Sao Paulo, Copenhagen University Hospital at Herlev, Sunnybrook Health Sciences Centre, Yale University

Conditions

BleedingBleeding DisorderBlood Coagulation DisordersC.Surgical Procedure; CardiacCIDPCardiac Surgical ProceduresCoagulopathyCoagulopathy in Patients Having Thoraco-Abdominal Aneurysm Repair

Phase 1

Fibrinogen in the Initial Resuscitation of Severe Trauma (FiiRST)

CompletedNCT02203968

Sunnybrook Health Sciences CentreBleeding, Coagulopathy, Haemorrhage +2

Start: 2014-10-31End: 2015-12-31Updated: 2016-04-14

A Program to Evaluate Riastap® and FIBTEM® for the Early Control and Treatment of Postpartum Hemorrhage (PERFECT PPH)

WithdrawnNCT02528708

Yale UniversityPostpartum Hemorrhage

Start: 2021-01-31End: 2021-12-31Updated: 2021-03-15

Phase 2

Fibrinogen Concentrate In Children After Cardiac Surgery

CompletedNCT01187225

University of Sao PauloBlood Coagulation Disorders, Cardiac Surgical Procedures, Cryoprecipitate +1

Start: 2010-08-31End: 2011-11-30Updated: 2013-01-04

Fibrinogen Concentrate as Initial Treatment for Postpartum Haemorrhage: A Randomised Clinically Controlled Trial

CompletedNCT01359878

Copenhagen University Hospital at HerlevPostpartum Haemorrhage

Start: 2011-05-31End: 2013-07-31Updated: 2013-09-20

Safety and Efficacy of Fibrinogen Concentrate in Aortic Arch Surgery Involving Moderate Hypothermic Circulatory Arrest

Hongjia ZhangProximal Aortic Dissection

Start: 2013-07-31End: 2016-08-31Target: 150Updated: 2015-09-07

Fibrinogen Early In Severe Trauma studY

CompletedNCT02745041

Gold Coast Hospital and Health ServiceCoagulopathy, Haemorrhage, Trauma

Start: 2016-12-31End: 2018-02-20Updated: 2018-03-05

Fibrinogen Early In Severe Trauma studY Junior

Gold Coast Hospital and Health ServiceCoagulopathy, Hemorrhage, Pediatrics +1

Start: 2018-07-01End: 2021-06-30Target: 44Updated: 2020-06-29

Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery

Sahlgrenska University HospitalCongenital Heart Disease

Start: 2018-03-14End: 2022-08-31Target: 40Updated: 2021-03-19

Phase 3

Fibrinogen Early In Severe Trauma StudY II

RecruitingNCT05449834

Australian and New Zealand Intensive Care Research CentreCoagulopathy, Haemorrhagic Shock, Trauma

Start: 2022-11-21End: 2026-12-01Target: 900Updated: 2026-02-05

Phase 4

Fibrinogen as an Alternative to FFP in Aortic Surgery.

CompletedNCT00994045

University of EdinburghCoagulopathy in Patients Having Thoraco-Abdominal Aneurysm Repair

Start: 2010-06-30Updated: 2017-01-31

Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial

CompletedNCT02864875

University of Sao Paulo General HospitalBleeding Disorder, Fibrinogen; Deficiency, Acquired, Trauma

Start: 2015-12-31End: 2018-07-31Updated: 2018-08-01

Fibrinogen Concentrate vs Cryoprecipitate

CompletedNCT03014700

Stanford UniversityCongenital Heart Disease

Start: 2016-03-31End: 2018-04-25Updated: 2019-05-07

Fibrinogen Concentrate In Children Cardiac Surgery 2

Filomena R B G GalasBlood Coagulation Disorders, C.Surgical Procedure; Cardiac, Hypofibrinogenemia

Start: 2019-03-01End: 2019-06-30Target: 42Updated: 2019-03-21

Unknown Phase

Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation

University Medical Centre LjubljanaCIDP, Good Pasture Syndrome, Guillain-Barre Syndrome +3

Start: 2018-10-03End: 2019-09-24Target: 20Updated: 2019-01-11

Pre-hospital Administration of Fibrinogen in Trauma-Induced Coagulopathy

Not yet recruitingNCT06582420

Unidade Local de Saude do Arco RibeirinhoTrauma Induced Coagulopathy

Start: 2025-01-01End: 2025-12-31Target: 52Updated: 2024-09-19

Related Papers

Integrating Research Practice Into Resuscitation Simulation Training Improves Recruitment Into Complex Clinical Trials

Emergency Medicine Australasia2025-05-271 citations

A Pilot Study on the Replacement of Fibrinogen with Fibrinogen Concentrates During Therapeutic Plasma Exchange with Mild to Moderate Bleeding Risk—A Comparison with Fresh Frozen Plasma and Albumin Replacement

Journal of Clinical Medicine2024-12-163 citations

Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial.

2022-09-2615 citations

Fibrinogen Early In Severe paediatric Trauma studY (FEISTY junior): protocol for a randomised controlled trial

BMJ Open2022-05-016 citations

Early administration of fibrinogen concentrate in patients with polytrauma with thromboelastometry suggestive of hypofibrinogenemia: A randomized feasibility trial.

2021-11-086 citations

Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial

Critical Care2018-06-18100 citations

Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial.

2017-05-2643 citations

Pilot Randomized trial of Fibrinogen in Trauma Haemorrhage (PRooF-iTH): study protocol for a randomized controlled trial.

2016-07-1919 citations

Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial.

2015-01-13163 citations

The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial.

2012-07-1728 citations