Fenfluramine

DRUG11 trials

Conditions

CDKL5 Deficiency DisorderChildren Under 2 YearsCocaine-Related DisordersCognitive FunctionContinuous Spike and Waves During Slow SleepDravet SyndromeDravet Syndrome (DS)Dravet Syndrome, Intractable

Phase 1

Predictive Values of Serotonergic Alterations for Outcome - 2

TerminatedNCT00000313

National Institute on Drug Abuse (NIDA)Cocaine-Related Disorders

Updated: 2017-01-12

Phase 2

Cardiovascular System in Obesity: Effect of Treatment

CompletedNCT00000506

National Heart, Lung, and Blood Institute (NHLBI)Heart Diseases, Obesity, Vascular Diseases

Start: 1983-05-31End: 1988-04-30Updated: 2013-11-26

Add-on Therapy With Low Dose Fenfluramine in Lennox Gastaut Epilepsy

NCT02655198

KU LeuvenEpilepsy, Lennox Gastaut Syndrome

Start: 2016-01-31End: 2024-12-31Updated: 2023-09-22

Treatment of Refractory Infantile Spasms With Fenfluramine

RecruitingNCT04289467

Children's Hospital of Orange CountyInfantile Spasm

Start: 2023-06-16End: 2026-12-31Target: 10Updated: 2026-04-15

Phase 3

A Phase 3 Study to Examine the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder.

Active, not recruitingNCT05064878

Zogenix, Inc.CDKL5 Deficiency Disorder, Epileptic Spasm, Generalized Tonic Clonic Seizure +1

Start: 2022-03-08End: 2027-11-08Updated: 2026-04-29

Fenfluramine for Adult Dravet Patients

TerminatedNCT05560282

University Health Network, TorontoDravet Syndrome, Dravet Syndrome, Intractable

Start: 2023-01-11End: 2025-05-13Updated: 2026-05-05

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Fenfluramine (Hydrochloride) in Infants 1 Year to Less Than 2 Years of Age With Dravet Syndrome

CompletedNCT06118255

UCB BIOSCIENCES, Inc.Dravet Syndrome

Start: 2024-05-21End: 2026-09-01Updated: 2026-09-17

Phase 4

Fenfluramine and Cognition

CompletedNCT05026398

University of OxfordCognitive Function

Start: 2021-04-12End: 2022-06-22Updated: 2022-11-15

Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Trial Exploring Epileptic and Non-epileptic Outcomes

RecruitingNCT05232630

Hospital Ruber InternacionalContinuous Spike and Waves During Slow Sleep, Inv Dup(15) Encephalopathy, Multifocal or Bilateral Malformations of Cortical Development +3

Start: 2022-10-20End: 2025-06-20Target: 20Updated: 2024-02-28

Assessment of Safety of the Use of Fenfluramine in Children With Dravet Syndrome Under 24 Months of Age

RecruitingNCT06598449

University of Colorado, DenverChildren Under 2 Years, Dravet Syndrome (DS)

Start: 2024-10-22End: 2027-07-01Target: 5Updated: 2026-05-15

Unknown Phase

Treatment of Dravet Syndrome With Fenfluramine (Expanded Access Protocol)

NCT04437004

University of California, Los AngelesDravet Syndrome

Updated: 2026-04-20

Related Papers

A pilot, open-label study of the effectiveness and tolerability of low-dose ZX008 (fenfluramine HCl) in Lennox-Gastaut syndrome.

2018-08-2647 citations