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Fedratinib

DRUG15 trials

Sponsors

Bristol-Myers Squibb Services Unlimited Company, Celgene Corp., Celgene, University of Washington, Bristol-Myers Squibb

Conditions

Acute Myeloid LeukemiaBlood CancerDIPSS-Intermediate or High Risk MyelofibrosisEssential ThrombocythemiaHealthy VolunteersHepatic ImpairmentIDH MutationIDH1 Mutation

Phase 1

Effect of Rifampin and Efavirenz on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects
CompletedNCT03983239
CelgeneHealthy Volunteers
Start: 2019-06-21End: 2019-11-06Updated: 2020-08-21
A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment
CompletedNCT03983161
CelgeneHealthy Volunteers, Hepatic Impairment
Start: 2019-09-04End: 2023-01-05Updated: 2023-03-17
Influence of Fedratinib on the Pharmacokinetics of the Transporter Probe Substrates Digoxin, Rosuvastatin, and Metformin
CompletedNCT04231435
CelgeneHealthy Volunteers
Start: 2019-12-18End: 2020-02-21Updated: 2020-05-21
A Study of Fedratinib in Japanese Subjects With DIPSS (Dynamic International Prognostic Scoring System)- Intermediate or High-risk Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (Post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)
Active, not recruitingNCT04446650
Bristol-Myers SquibbPrimary Myelofibrosis
Start: 2020-10-12End: 2026-11-30Updated: 2025-10-21
A Study to Evaluate the Effect of a Dual CYP2C19 and CYP3A4 Inhibitor, Fluconazole, on the Pharmacokinetics of Fedratinib in Healthy Adult Subjects
CompletedNCT04702464
CelgeneHealthy Volunteers
Start: 2021-01-12End: 2021-05-13Updated: 2021-11-29
A Study to Assess the Safety and Tolerability of BMS-986158 Alone and in Combination With Either Ruxolitinib or Fedratinib in Participants With Blood Cancer (Myelofibrosis)
Active, not recruitingNCT04817007
Bristol-Myers SquibbMyelofibrosis
Start: 2021-03-22End: 2026-05-31Target: 216Updated: 2025-09-10
A Study of Fedratinib With IDH Inhibition in Advanced-Phase, IDH-Mutated Ph-Negative Myeloproliferative Neoplasms
WithdrawnNCT04955938
University of ChicagoBlood Cancer, IDH1 Mutation, IDH2 Gene Mutation +2
Start: 2021-10-29End: 2023-06-07Updated: 2024-07-31
A Study to Evaluate the Bioavailability of Fedratinib When Administered in Different Ways to Healthy Adult Participants
CompletedNCT05051553
Bristol-Myers SquibbHealthy Volunteers
Start: 2021-09-21End: 2022-04-08Updated: 2022-06-27
A Phase 1b/2 Study of BMS-986158 Monotherapy and in Combination with Either Ruxolitinib or Fedratinib in Participants with DIPSS-Intermediate or High Risk Myelofibrosis
Active, not recruitingCTIS2023-509635-89-00
Bristol-Myers Squibb Services Unlimited CompanyDIPSS-Intermediate or High Risk Myelofibrosis
Start: 2021-06-01Target: 132Updated: 2026-01-12

Phase 2

Phase 3

Unknown Phase

Related Papers

4 more papers not shown