Fecal Microbiota Transplantation Capsule

DRUG5 trials

Sponsors

Jonsson Comprehensive Cancer Center, M.D. Anderson Cancer Center, Fred Hutchinson Cancer Center, Sixth Affiliated Hospital, Sun Yat-sen University

Conditions

Acute Graft Versus Host DiseaseGastrointestinal Tract Acute Graft Versus Host DiseaseHematopoietic and Lymphatic System NeoplasmMetastatic Colorectal AdenocarcinomaMetastatic Small Intestinal AdenocarcinomaPancreatic Ductal AdenocarcinomaRadiation Induced ProctitisSevere Gastrointestinal Tract Acute Graft Versus Host Disease

Early Phase 1

Fecal Microbial Transplants for the Treatment of Pancreatic Cancer

RecruitingNCT04975217

M.D. Anderson Cancer CenterPancreatic Ductal Adenocarcinoma

Start: 2021-12-14End: 2026-12-31Target: 10Updated: 2026-03-20

Phase 1

Fecal Microbiota Transplantation for the Treatment of Severe Acute Gut Graft-Versus-Host Disease

WithdrawnNCT04280471

Jonsson Comprehensive Cancer CenterAcute Graft Versus Host Disease, Gastrointestinal Tract Acute Graft Versus Host Disease, Severe Gastrointestinal Tract Acute Graft Versus Host Disease +1

Start: 2023-09-01End: 2025-12-01Updated: 2023-09-22

Phase 2

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders

Active, not recruitingNCT04729322

M.D. Anderson Cancer CenterMetastatic Colorectal Adenocarcinoma, Metastatic Small Intestinal Adenocarcinoma, Stage IVA Colorectal Cancer AJCC v8 +4

Start: 2021-02-22End: 2027-12-31Updated: 2025-12-23

Fecal Microbiota Transplantation for the Prevention of Acute Graft Versus Host Disease in Adults Undergoing Allogeneic Hematopoietic Cell Transplantation

Active, not recruitingNCT06026371

Fred Hutchinson Cancer CenterAcute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm

Start: 2023-12-12End: 2027-03-31Target: 138Updated: 2026-01-12

Fecal Microbiota Transplantation for Radiation-Induced Proctopathy

RecruitingNCT06776029

Sixth Affiliated Hospital, Sun Yat-sen UniversityRadiation Induced Proctitis

Start: 2025-02-01End: 2026-06-30Target: 20Updated: 2025-03-10

Related Papers

Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect.

2025-01-2517 citations

Fecal Microbiota Transplantation to Prevent Acute Graft-Versus-Host Disease: First Pre-Planned Interim Analysis of a Randomized Trial

Blood2024-11-051 citations