Fazirsiran
Sponsors
Takeda Development Center Americas Inc., Takeda
Conditions
Alpha-1 Antitrypsin Deficiency-Associated Liver DiseaseHepatic Impairment
Phase 1
Phase 3
A Randomized, Double-blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Fazirsiran in the Treatment of Alpha-1 Antitrypsin Deficiency–Associated Liver Disease With METAVIR Stage F2 to F4 Fibrosis
RecruitingCTIS2022-501943-34-00
Start: 2023-06-27Target: 103Updated: 2026-01-08
A Phase 3, Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Fazirsiran in Participants With Alpha-1 Antitrypsin Deficiency-Associated Liver Disease
RecruitingCTIS2023-503497-21-00
Start: 2023-07-24Target: 15Updated: 2025-12-15
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Fazirsiran in the Treatment of Alpha-1 Antitrypsin Deficiency-Associated Liver Disease With METAVIR Stage F1 Fibrosis
RecruitingCTIS2023-504198-19-00
Start: 2024-04-18Target: 25Updated: 2025-12-22