external beam radiation therapy (EBRT) + brachytherapy

RADIATION2 trials

Sponsors

AstraZeneca, Tongji Hospital

Conditions

Cervical CancerConcurrent ChemoradiotherapyLocally Advanced Cervical CancerNeoadjuvant Chemoimmunotherapy

Phase 2

Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC

RecruitingNCT06288373

Tongji HospitalCervical Cancer, Concurrent Chemoradiotherapy, Locally Advanced Cervical Cancer +1

Start: 2024-04-22End: 2031-03-01Target: 440Updated: 2024-10-30

Phase 3

Study of Durvalumab With Chemoradiotherapy for Women With Locally Advanced Cervical Cancer (CALLA)

CompletedNCT03830866

AstraZenecaLocally Advanced Cervical Cancer

Start: 2019-02-15End: 2023-07-03Updated: 2024-07-26

Related Papers

Ultrasensitive detection and tracking of circulating tumor DNA to predict relapse and survival in patients with locally advanced cervical cancer: phase III CALLA trial analyses.

2025-06-025 citations

Ultrasensitive detection and tracking of circulating tumor DNA (ctDNA) and association with relapse and survival in locally advanced cervical cancer (LACC): Phase 3 CALLA trial analyses.

Journal of Clinical Oncology2025-05-285 citations

Phase I Trial of First-line Bintrafusp Alfa in Patients with Locally Advanced or Persistent/Recurrent/Metastatic Cervical Cancer

Clinical Cancer Research2024-01-028 citations

Durvalumab versus placebo with chemoradiotherapy for locally advanced cervical cancer (CALLA): a randomised, double-blind, phase 3 trial.

2023-12-01134 citations

Nivolumab plus chemoradiotherapy in locally-advanced cervical cancer: the NICOL phase 1 trial

Nature Communications2023-06-2247 citations

Incorporation of triapine (T) with cisplatin chemoradiation (CRT) for locally advanced cervical and vaginal cancer: Results from NRG-GY006, a phase III randomized trial.

Journal of Clinical Oncology2023-06-0111 citations

O001/#504 Durvalumab, in combination with and following chemoradiotherapy, in locally advanced cervical cancer: results from the phase 3 international, randomized, double-blind, placebo-controlled calla trial

2022-12-0115 citations

Concurrent chemoradiation and brachytherapy alone or in combination with nelfinavir in locally advanced cervical cancer (NELCER): study protocol for a phase III trial

BMJ Open2022-04-0113 citations

CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study

International Journal of Gynecological Cancer2020-05-2386 citations

Letter to the editor, Reply to: Lee and Matulonis: Immunotherapy and radiation combinatorial trials in gynecologic cancer: A potential synergy?

2019-10-101 citations

CALLA: Efficacy and safety of durvalumab with and following concurrent chemoradiotherapy (CCRT) versus CCRT alone in women with locally advanced cervical cancer: A phase III, randomized, double-blind, multicenter study.

Journal of Clinical Oncology2019-05-2011 citations