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Extended-Release Naltrexone
DRUG
5 trials
Sponsors
NYU Langone Health
, Yale University
, University of Texas Southwestern Medical Center
Conditions
AIDS
Cocaine Use Disorder
Drug Dependence
HIV
Heroin Dependence
Opiate Dependence
Opioid Dependence
Opioid Use Disorder
+1 more
Phase 1
Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations
Completed
NCT01246401
Yale University
AIDS, Drug Dependence, HIV +1
Start: 2011-03-31
End: 2016-07-31
Updated: 2020-03-19
Phase 2
Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)
Completed
NCT05262270
University of Texas Southwestern Medical Center
Cocaine Use Disorder
Start: 2023-04-18
End: 2025-07-21
Updated: 2025-10-21
Phase 3
Extended-Release Naltrexone for Opioid Relapse Prevention Following Release From Jail
Completed
NCT01180647
NYU Langone Health
Opiate Dependence
Start: 2010-05-31
End: 2013-07-31
Updated: 2016-04-07
Phase 4
Extended-Release Naltrexone Opioid Treatment at Jail Re-Entry
Completed
NCT01999946
NYU Langone Health
Heroin Dependence, Opioid-Related Disorders
Start: 2014-06-27
End: 2020-12-24
Updated: 2021-06-25
Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment
Completed
NCT02032433
NYU Langone Health
Opioid Use Disorder
Start: 2014-01-29
End: 2017-01-31
Updated: 2020-08-13
Related Papers
Suicidal ideation in adults with opioid use disorder treated with buprenorphine-naloxone versus extended-release naltrexone
The American Journal of Drug and Alcohol Abuse
2025-07-11
Randomized, placebo-controlled trial of injectable extended-release naltrexone and injectable extended-release buprenorphine for cocaine use disorder (CURB-2): Study rationale and design.
2025-05-11
Methamphetamine/amphetamine use over time among persons with opioid use disorders treated with buprenorphine/naloxone versus extended-release naltrexone.
2022-04-21
3 citations
Co-occurring Depression and Suicidal Ideation in Opioid Use Disorder
The Journal of Clinical Psychiatry
2022-04-15
11 citations
Association between methadone or buprenorphine use during medically supervised opioid withdrawal and extended-release injectable naltrexone induction failure.
2021-01-16
11 citations
Perceptions of extended-release naltrexone, methadone, and buprenorphine treatments following release from jail
Addiction Science & Clinical Practice
2019-10-01
52 citations
Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial.
2017-11-14
499 citations
NIDA Clinical Trials Network CTN-0051, Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT): Study design and rationale.
2016-08-10
53 citations
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for HIV-infected, opioid dependent prisoners and jail detainees who are transitioning to the community.
2014-09-18
30 citations