Extended Release Metformin Hydrochloride

DRUG5 trials

Sponsors

Northwestern University, M.D. Anderson Cancer Center, University of Arizona, City of Hope Medical Center

Conditions

Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Breast Ductal Carcinoma In SituEndometrial Atypical Hyperplasia/Endometrioid Intraepithelial NeoplasiaEndometrial CarcinomaErythroplakiaInvasive Breast Carcinoma

Phase 2

Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

Active, not recruitingNCT04576104

Northwestern UniversityEndometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Carcinoma

Start: 2021-11-29End: 2026-06-30Updated: 2026-01-21

Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer

Active, not recruitingNCT04931017

Northwestern UniversityLung Carcinoma

Start: 2022-09-09End: 2027-06-30Updated: 2025-10-07

Metformin and Nightly Fasting in Women With Early Breast Cancer

Active, not recruitingNCT05023967

M.D. Anderson Cancer CenterAnatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Breast Ductal Carcinoma In Situ +1

Start: 2023-04-04End: 2026-12-16Updated: 2026-01-05

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Active, not recruitingNCT05237960

University of ArizonaErythroplakia, Oral Leukoplakia

Start: 2023-01-12End: 2026-12-31Updated: 2025-09-29

Phase 3

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

RecruitingNCT06763328

City of Hope Medical CenterAnatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 +1

Start: 2024-12-16End: 2029-06-16Target: 200Updated: 2026-01-22

Related Papers

Clinical Management Update of Oral Leukoplakia: A Review From the American Head and Neck Society Cancer Prevention Service.

2024-11-255 citations

Metformin for chemoprevention of lung cancer in high-risk overweight or obese individuals.

Journal of Clinical Oncology2023-06-011 citations

Surgical window-of-opportunity study of megestrol acetate compared with megestrol acetate and metformin for endometrial intraepithelial neoplasia.

Journal of Clinical Oncology2022-06-01