EXL01
Sponsors
Centre Hospitalier Universitaire De Lille, Hospices Civils De Lyon, Gercor, Centre De Lutte Contre Le Cancer Eugene Marquis, Groupe De Recherche Sur Les Maladies Inflammatoires Digestives, Groupe De Recherche Sur Les Maladies Inflammatoires Digestives
Conditions
Clostridioides Difficile InfectionCrohn DiseaseCrohn's diseaseGastric CancerHepatocellular CarcinomaHepatocellular carcinomaMultiple recurrences of Clostridioides difficile infection treated with oral VancomycinNon-Small Cell Lung Cancer
Phase 1
EXL01 in the Maintenance of Steroid-induced Clinical Response/Remission in Participants With Mild to Moderate Crohn's Disease
TerminatedNCT05542355
Start: 2023-03-20End: 2024-10-02Updated: 2024-10-10
Evaluation of EXL01 a new Live Biotherapeutic Product to prevent recurrence of Clostridioides difficile infection in high-risk patients. LIVEDIFF
RecruitingCTIS2023-506232-32-00
Start: 2024-04-08Target: 56Updated: 2026-01-23
Evaluation of EXL01, a New Live Biotherapeutic Product to Prevent Recurrence of Clostridioides Difficile Infection in High-risk Patients
RecruitingNCT06306014
Start: 2024-05-07End: 2027-01-07Target: 56Updated: 2026-03-02
EXL-01 in combination with nivolumab for advanced NSCLC refractory to immunotherapy'
RecruitingCTIS2023-505285-28-01
Start: 2024-07-16Target: 21Updated: 2025-07-31
EXL01 in Combination With Nivolumab for Advanced NSCLC Refractory to Immunotherapy.
RecruitingNCT06448572
Start: 2024-07-16End: 2028-10-01Target: 21Updated: 2025-09-25
Phase 2
Gut microbiome intervention with EXL01 in combination with nivolumab and FOLFOX as first-line treatment for patients with PD-L1 CPS ≥5 metastatic gastric cancer: A randomized GERCOR phase II study (BIG)
RecruitingCTIS2023-506753-38-00
Start: 2024-04-16Target: 120Updated: 2025-10-02
First-line EXL01 With Nivolumab and FOLFOX for PD-L1 CPS ≥5 Metastatic Gastric Cancer
RecruitingNCT06253611
Start: 2024-04-16End: 2029-04-30Target: 120Updated: 2025-09-22
MICROBIOTA MODIFICATION FOR IMMUNO-ONCOLOGY IN HEPATOCELLULAR CARCINOMA - “MOTHER”
RecruitingCTIS2023-508201-25-00
Start: 2025-03-12Target: 34Updated: 2025-12-22
Microbiota Modification for Immuno-oncology in Hepatocellular Carcinoma
RecruitingNCT06551272
Start: 2025-03-12End: 2026-12-12Target: 34Updated: 2025-08-05
A Phase 2 multicentre, randomised, parallel-arm, placebo-controlled, double-blind study to evaluate the safety and target engagement of EXL01 in the prevention of post-operative recurrence of Crohn’s Disease
RecruitingCTIS2024-511357-22-00
Start: 2025-03-31Target: 80Updated: 2025-04-07