Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells

BIOLOGICAL3 trials

Sponsors

University of Florida

Conditions

Brain MetastasesDiffuse Intrinsic Pontine GliomaGlioblastomaGlioblastoma MultiformeHigh-grade Glioma

Phase 1

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

RecruitingNCT05353530

University of FloridaGlioblastoma, Glioblastoma Multiforme

Start: 2023-07-25End: 2042-12-01Target: 39Updated: 2026-05-27

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG)

Not yet recruitingNCT06946680

University of FloridaDiffuse Intrinsic Pontine Glioma, High-grade Glioma

Start: 2026-11-01End: 2045-12-01Target: 24Updated: 2026-09-09

IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases

Not yet recruitingNCT07569263

University of FloridaBrain Metastases

Start: 2026-10-01End: 2044-12-01Target: 12Updated: 2026-09-09

Related Papers

CTIM-21. FIRST-IN-HUMAN PHASE I CLINICAL TRIAL USING 8R-70CAR T CELLS FOR NEWLY DIAGNOSED ADULT GLIOBLASTOMA

Neuro-Oncology2024-11-011 citations

269 CAR T cell production expands endogenous T cell repertoire recognizing additional tumor antigen(s)

Regular and Young Investigator Award Abstracts2023-10-31