EV71 vaccine

BIOLOGICAL12 trials

Sponsors

National Health Research Institutes, Taiwan, Sinovac Biotech Co., Ltd, Chinese Academy of Medical Sciences, Jiangsu Province Centers for Disease Control and Prevention, Medigen Vaccine Biologics Corp.

Conditions

EV71 VaccineEnterovirus 71 HumanEnterovirus 71 InfectionEnterovirus InfectionEnterovirus InfectionsHand, Foot and Mouth DiseaseHand, Foot and Mouth Disease (HFMD)Hand, Foot, and Mouth Disease (HFMD)

Phase 1

A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine

CompletedNCT01268787

National Health Research Institutes, TaiwanEnterovirus Infection

Start: 2010-12-31End: 2012-09-30Updated: 2015-04-16

Phase 3

A Study to Evaluate the Efficacy, Immunogenicity and Safety of an EV71 Vaccine in Healthy Infants and Children

CompletedNCT05099029

Enimmune CorporationEnterovirus Infections

Start: 2018-06-27End: 2024-07-31Updated: 2026-09-11

Phase 4

Phase IV Clinical Trial, Immunogenicity and Safety of EV71 Vaccine

CompletedNCT03278132

Sinovac Biotech Co., LtdHand, Foot and Mouth Disease

Start: 2017-07-16End: 2017-09-15Updated: 2019-01-02

The Phase IVd of Inactivated Enterovirus 71 Vaccine

Chinese Academy of Medical SciencesHand, Foot and Mouth Disease (HFMD)

Start: 2017-09-14End: 2019-09-02Target: 1220Updated: 2017-09-28

Efficacy Evaluation for Inactivated Vaccine (Vero Cell) Against EV71

CompletedNCT03582761

Jiangsu Province Centers for Disease Control and PreventionHand, Foot and Mouth Disease

Start: 2019-05-01End: 2020-05-01Updated: 2021-05-24

Evaluation of the Safety and Immunogenicity of Simultaneously Administration of EV71 Vaccine and Influenza Vaccine

CompletedNCT04091880

China National Biotec Group Company LimitedEnterovirus Infections, Influenza

Start: 2019-09-26End: 2021-08-10Updated: 2022-10-12

Lot-to-lot Consistency Study of Three Commercial Batches of Enterovirus 71 Vaccine

RecruitingNCT06146088

Institute of Medical Biology, Chinese Academy of Medical SciencesHand, Foot and Mouth Disease

Start: 2023-11-25End: 2026-07-15Target: 1500Updated: 2024-01-03

Clinical Trial for Batch Consistency of EV71 Vaccine

CompletedNCT07026500

Sinovac Biotech Co., LtdEV71 Vaccine

Start: 2019-09-19End: 2020-05-31Updated: 2025-06-18

Unknown Phase

A Follow-up Study for a Phase III, Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine

CompletedNCT02001233

Sinovac Biotech Co., LtdHand, Foot and Mouth Disease

Start: 2013-03-31End: 2014-10-31Updated: 2022-05-26

Long-Term Immunogenicity Study of Inactivated EV71 Vaccine in Children

CompletedNCT04072276

Medigen Vaccine Biologics Corp.Enterovirus 71 Human

Start: 2019-08-15End: 2021-12-11Updated: 2022-09-30

Long-Term Immunogenicity of Envacgen® in Children

Active, not recruitingNCT07568522

Medigen Vaccine Biologics Corp.Enterovirus 71 Human

Start: 2025-11-24End: 2026-07-31Updated: 2026-05-05

Bridging Clinical Trial of EV71 Vaccine in Vietnamese Children

Not yet recruitingNCT07793175

Sinovac Biotech Co., LtdEnterovirus 71 Infection, Hand, Foot, and Mouth Disease (HFMD)

Start: 2026-09-19End: 2027-07-16Target: 320Updated: 2026-09-01

Related Papers

A randomised trial of a bioreactor-produced EV-A71 vaccine for endemic control in children.

2026-02-12

Immunogenicity and safety of an inactivated enterovirus 71 vaccine coadministered with trivalent split-virion inactivated influenza vaccine: A phase 4, multicenter, randomized, controlled trial in China

Frontiers in Immunology2022-12-084 citations

Short-term dynamic changes in neutralizing antibodies against enterovirus 71 after vaccination

Human Vaccines & Immunotherapeutics2020-01-244 citations

Effectiveness of the inactivated enterovirus 71 vaccine in children aged 6–35 months: protocol for a multicentre, case-control phase IV clinical trial

Journal of Public Health and Emergency2019-12-01

Formalin-Inactivated EV71 Vaccine Candidate Induced Cross-Neutralizing Antibody against Subgenotypes B1, B4, B5 and C4A in Adult Volunteers

PLoS ONE2013-11-2189 citations

A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine.

2013-03-2760 citations