Etidronate

DRUG5 trials

Sponsors

Organon and Co, National Heart, Lung, and Blood Institute (NHLBI), UMC Utrecht, Suez Canal University

Conditions

AdenocarcinomaArterial CalcificationCD73 DeficiencyEndodontic TreatmentEsophageal CancerFahr DiseaseFahr SyndromeInflammation

Phase 2

Etidronate for Arterial Calcifications Due to Deficiency in CD73 (ACDC)

CompletedNCT01585402

National Heart, Lung, and Blood Institute (NHLBI)Arterial Calcification, CD73 Deficiency

Start: 2012-08-20End: 2021-08-06Updated: 2022-10-04

Treatment of Ectopic Calcification in Fahr's Disease or Syndrome

RecruitingNCT05662111

UMC UtrechtFahr Disease, Fahr Syndrome, Primary Familial Brain Calcification

Start: 2023-04-03End: 2027-12-01Target: 98Updated: 2026-03-02

Phase 3

The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum

RecruitingNCT05832580

UMC UtrechtPseudoxanthoma Elasticum

Start: 2023-04-26End: 2027-04-29Target: 76Updated: 2023-04-27

Unknown Phase

Observational Study of Incidence Rates of Esophageal Cancer in Women Taking Medications for the Prevention or Treatment of Osteoporosis (MK-0217A-352)

CompletedNCT01077817

Organon and CoAdenocarcinoma, Esophageal Cancer, Squamous Cell Carcinoma

Start: 2010-02-26End: 2012-02-16Updated: 2022-02-03

Effect of Different Irrigation Protocols on Postoperative Endodontic Pain and Inflammation

Active, not recruitingNCT07116252

Suez Canal UniversityEndodontic Treatment, Inflammation, Irrigation Solution +1

Start: 2023-08-20End: 2025-12-31Updated: 2025-08-11

Related Papers

The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum.

2025-10-23

Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC)

Vascular Medicine2024-04-0312 citations

The effects of etidronate on brain calcifications in Fahr's disease or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial.

2024-02-0710 citations

Isolated arterial calcifications of the lower extremities: A clue for NT5E mutation

International Journal of Cardiology2016-03-1914 citations