Etentamig
Sponsors
AbbVie Deutschland GmbH & Co. KG, AbbVie, Mayo Clinic, Universitätsklinikum Hamburg-Eppendorf
Conditions
Amyloid Light Chain (AL) AmyloidosisMultiple MyelomaMultiple Myeloma (MM)MyelomaMyeloma MultipleRecurrent Waldenstrom MacroglobulinemiaRefractory Waldenstrom MacroglobulinemiaRelapsed or Refractory Multiple Myeloma
Phase 1
A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
Active, not recruitingNCT05259839
Start: 2022-10-20End: 2033-09-01Updated: 2026-08-14
A Study to Assess Adverse Events and Change in Disease State of Intravenously (IV) Infused Etentamig (ABBV-383) of Adult Participants With Relapsed or Refractory Multiple Myeloma in Japan
Active, not recruitingNCT05286229
Start: 2022-03-24End: 2026-03-31Updated: 2025-08-08
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
RecruitingNCT06892522
Start: 2025-06-30End: 2035-12-01Target: 602Updated: 2026-07-21
Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma
RecruitingNCT06896916
Start: 2025-08-07End: 2036-03-01Target: 135Updated: 2026-05-12
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
RecruitingNCT06953960
Start: 2025-07-23End: 2030-12-01Target: 325Updated: 2026-09-11
A Phase 1/2, Open-Label, Platform Study to Evaluate Safety and Efficacy of Etentamig Monotherapy or Etentamig Combinations in Subjects with Multiple Myeloma
Not yet recruitingCTIS2024-515770-27-00
Target: 10Updated: 2026-01-27
ABBV-383 for the Treatment of Relapsed Refractory Waldenström Macroglobulinemia
Not yet recruitingNCT07420959
Start: 2026-10-25End: 2038-10-25Target: 38Updated: 2026-07-08
Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple Myeloma
Not yet recruitingNCT07600151
Start: 2026-12-01End: 2036-12-31Target: 220Updated: 2026-05-20
A Phase 1/2, Open-Label, Platform Study to Evaluate Safety and Efficacy of the BCL-2 Inhibitor Surzetoclax (ABBV-453) given as Monotherapy or in Combination with Antimyeloma Regimens in Subjects with Multiple Myeloma
Not yet recruitingCTIS2025-525105-20-00
Target: 76Updated: 2026-07-14
Phase 2
A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
RecruitingNCT07095452
Start: 2026-01-08End: 2042-01-01Target: 660Updated: 2026-06-11
A Phase 2/3, Multicenter, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Subjects with Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
Not yet recruitingCTIS2025-520897-21-00
Target: 24Updated: 2026-02-18
Phase 3
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
Active, not recruitingNCT06158841
Start: 2024-05-19End: 2027-12-01Updated: 2026-08-27
A Phase 3, Multicenter, Randomized, Open Label Study of Etentamig Compared With Standard Available Therapy in Subjects With Relapsed or Refractory Multiple Myeloma (3L+ RRMM Monotherapy Study)
RecruitingCTIS2023-506668-15-00
Start: 2024-06-17Target: 147Updated: 2025-11-12
A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma
Not yet recruitingNCT07728188
Start: 2026-11-30End: 2033-02-01Target: 520Updated: 2026-07-27
Study to Evaluate Change in Disease Activity and Adverse Events of Subcutaneous Etentamig Compared With Daratumumab Plus Cyclophosphamide Plus Bortezomib Plus Dexamethasone (Dara-CyBorD) in Adults With Amyloid Light Chain (AL) Amyloidosis
Not yet recruitingNCT07793422
Start: 2026-11-29End: 2034-12-01Target: 370Updated: 2026-08-28