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Etentamig

DRUG15 trials

Sponsors

AbbVie Deutschland GmbH & Co. KG, AbbVie, Mayo Clinic, Universitätsklinikum Hamburg-Eppendorf

Conditions

Amyloid Light Chain (AL) AmyloidosisMultiple MyelomaMultiple Myeloma (MM)MyelomaMyeloma MultipleRecurrent Waldenstrom MacroglobulinemiaRefractory Waldenstrom MacroglobulinemiaRelapsed or Refractory Multiple Myeloma

Phase 1

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma
Active, not recruitingNCT05259839
AbbVieRelapsed/Refractory Multiple Myeloma
Start: 2022-10-20End: 2033-09-01Updated: 2026-08-14
A Study to Assess Adverse Events and Change in Disease State of Intravenously (IV) Infused Etentamig (ABBV-383) of Adult Participants With Relapsed or Refractory Multiple Myeloma in Japan
Active, not recruitingNCT05286229
AbbVieRelapsed/Refractory Multiple Myeloma
Start: 2022-03-24End: 2026-03-31Updated: 2025-08-08
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
RecruitingNCT06892522
AbbVieMultiple Myeloma
Start: 2025-06-30End: 2035-12-01Target: 602Updated: 2026-07-21
Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma
RecruitingNCT06896916
AbbVieMultiple Myeloma
Start: 2025-08-07End: 2036-03-01Target: 135Updated: 2026-05-12
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
RecruitingNCT06953960
AbbVieMultiple Myeloma
Start: 2025-07-23End: 2030-12-01Target: 325Updated: 2026-09-11
A Phase 1/2, Open-Label, Platform Study to Evaluate Safety and Efficacy of Etentamig Monotherapy or Etentamig Combinations in Subjects with Multiple Myeloma
Not yet recruitingCTIS2024-515770-27-00
AbbVie Deutschland GmbH & Co. KGMultiple Myeloma
Target: 10Updated: 2026-01-27
ABBV-383 for the Treatment of Relapsed Refractory Waldenström Macroglobulinemia
Not yet recruitingNCT07420959
Mayo ClinicRecurrent Waldenstrom Macroglobulinemia, Refractory Waldenstrom Macroglobulinemia
Start: 2026-10-25End: 2038-10-25Target: 38Updated: 2026-07-08
Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple Myeloma
Not yet recruitingNCT07600151
Universitätsklinikum Hamburg-EppendorfMyeloma, Myeloma Multiple
Start: 2026-12-01End: 2036-12-31Target: 220Updated: 2026-05-20
A Phase 1/2, Open-Label, Platform Study to Evaluate Safety and Efficacy of the BCL-2 Inhibitor Surzetoclax (ABBV-453) given as Monotherapy or in Combination with Antimyeloma Regimens in Subjects with Multiple Myeloma
Not yet recruitingCTIS2025-525105-20-00
AbbVie Deutschland GmbH & Co. KGMultiple Myeloma (MM)
Target: 76Updated: 2026-07-14

Phase 2

Phase 3

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