Erwinia asparaginase

DRUG6 trials

Sponsors

St. Jude Children's Research Hospital, Dana-Farber Cancer Institute, Andrew E. Place, MD

Conditions

Acute Leukemia of Ambiguous LineageAcute Leukemia of Ambiguous Lineage in RelapseAcute Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia With Failed RemissionAcute Lymphoblastic Leukemia, PediatricAcute Lymphoblastic Leukemia, in RelapseAcute Myeloid LeukemiaLymphoblastic Lymphoma

Phase 1

Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax

Active, not recruitingNCT05192889

St. Jude Children's Research HospitalRefractory Acute Lymphoblastic Leukemia, Relapsed Acute Lymphoblastic Leukemia

Start: 2022-08-25End: 2027-02-28Updated: 2025-09-22

Venetoclax Basket Trial for High Risk Hematologic Malignancies

RecruitingNCT05292664

Andrew E. Place, MDAcute Leukemia of Ambiguous Lineage, Acute Leukemia of Ambiguous Lineage in Relapse, Acute Lymphoblastic Leukemia, in Relapse +8

Start: 2023-03-29End: 2030-07-02Target: 30Updated: 2026-03-12

Phase 2

NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma

CompletedNCT01451515

St. Jude Children's Research HospitalLymphoblastic Lymphoma

Start: 2012-05-25End: 2022-05-31Updated: 2022-06-28

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

Active, not recruitingNCT03164057

St. Jude Children's Research HospitalAcute Myeloid Leukemia, Myelodysplastic Syndromes

Start: 2017-06-15End: 2027-06-01Updated: 2026-01-28

Phase 3

A Study of Children With Refractory or Relapsed ALL

CompletedNCT00187083

St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia

Start: 1997-02-28End: 2003-12-31Updated: 2008-06-04

Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Active, not recruitingNCT03020030

Dana-Farber Cancer InstituteAcute Lymphoblastic Leukemia, Pediatric

Start: 2017-03-03End: 2034-11-01Updated: 2026-01-22

Related Papers

Trajectory of Neurocognitive Functioning in Children Treated for Acute Lymphoblastic Leukemia (ALL): Dana-Farber Cancer Institute ALL Consortium Study 16-001.

2026-01-10

Data from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia

2025-11-03

Cumulative incidence of household material hardship and income loss as measures of financial toxicity during pediatric acute lymphoblastic leukemia (ALL) treatment: A report from the DFCI ALL 16-001 Trial

Blood2025-11-03

A phase I study of venetoclax in combination with multiagent cytotoxic chemotherapy for children and adolescents with relapsed or refractory acute lymphoblastic leukemia or mixed phenotype acute leukemia: Results of the dose determination cohort

Blood2025-11-03

Comparison of paired bone marrow and peripheral blood measurable residual disease in pediatric acute lymphoblastic leukemia by next-generation sequencing: A report from the dana farber ALL consortium protocol 16-001.

Blood2025-11-03

Epigenetic priming improves survival for pediatric Acute Myeloid Leukemia: Results from the multicenter randomized AML16 trial

Blood2025-11-03

Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia.

2025-11-01

Baseline Neurocognitive Functioning Among Children Treated for Acute Lymphoblastic Leukemia (ALL): Dana Farber Cancer Institute ALL Consortium Study 16‐001

Pediatric Blood & Cancer2025-05-131 citations

Public Insurance As a Proxy Measure of Household Poverty-Exposures Among Children with Hematologic Malignancies

Blood2024-11-051 citations

Household Material Hardship and Inpatient Days in Dana-Farber Cancer Institute (DFCI) Acute Lymphoblastic Leukemia (ALL) Consortium Trial 16-001

Blood2024-11-05

Supplemental Nutrition Assistance Program participation gaps within a pediatric leukemia clinical trial cohort

Pediatric Blood & Cancer2024-08-113 citations

Inequitable Poverty Exposures: A Subspecialty Opportunity to Address Disparities

Hospital Pediatrics2024-01-195 citations

Pediatric acute myeloid leukemia with breast chloromas

eJHaem2023-03-151 citations

Proteomic Analysis Identifies Epigenetic Modifiers and Potential Negative Regulators of Leukemogenesis KMD6A and SETDB1 to be Induced Post <i>In Vivo</i> Decitabine Exposure in Pediatric AML

Blood2022-11-15

Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001

Blood Advances2021-12-2178 citations

Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data.

2021-02-1710 citations

Epigenetic Regulation of OCTN1‐mediated Cytarabine Transport in Acute Myeloid Leukemia

The FASEB Journal2019-04-01