Erwinase

DRUG10 trials

Conditions

AML, ChildhoodAcute Lymphoblastic LeukemiaAcute Lymphoblastic Leukemia, PediatricAcute Myeloid LeukemiaAllergy to Native e.Coli AsparaginaseAllergy to PEG e.Coli AsparaginaseB Lymphoblastic LeukemiaHematologic Malignancy

Phase 1

Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins Lymphoma

CompletedNCT00693602

St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia, Non Hodgkins Lymphoma

Start: 2006-06-30End: 2011-12-31Updated: 2017-04-26

Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)

TerminatedNCT00928200

Therapeutic Advances in Childhood Leukemia ConsortiumAllergy to Native e.Coli Asparaginase, Allergy to PEG e.Coli Asparaginase, Relapsed Acute Lymphoblastic Leukemia

Start: 2009-04-13End: 2010-06-04Updated: 2019-02-19

1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)

CompletedNCT02283190

Ashkan EmadiAcute Myeloid Leukemia

Start: 2014-04-30End: 2017-09-30Updated: 2018-03-12

Phase 2

Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell Lymphoma

CompletedNCT00283985

University Hospital, LimogesLymphoma, Non-Hodgkin

Start: 2006-02-28End: 2012-06-30Updated: 2013-02-28

Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies

WithdrawnNCT02718755

M.D. Anderson Cancer CenterHematologic Malignancy

Start: 2018-05-31End: 2022-05-31Updated: 2018-06-26

AflacLL1901 (CHOA-AML)

TerminatedNCT04326439

Emory UniversityAcute Myeloid Leukemia, AML, Childhood

Start: 2020-01-24End: 2022-03-15Updated: 2022-06-15

Ma-Spore ALL 2020 Study

RecruitingNCT06336395

National University Hospital, SingaporeB Lymphoblastic Leukemia

Start: 2020-03-04End: 2030-03-31Target: 500Updated: 2024-03-28

Phase 3

Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

RecruitingNCT03643276

Martin SchrappeAcute Lymphoblastic Leukemia, Pediatric

Start: 2018-07-15End: 2028-07-14Target: 5000Updated: 2025-04-06

AIEOP-BFM ALL 2017 - International collaborative treatment protocol for children and adolescents with acute lymphoblastic leukemia

Active, not recruitingCTIS2023-509856-32-00

Universitaetsklinikum Schleswig-Holsteinacute lymphoblastic leukemia in children and adolescents

Start: 2018-07-15Target: 4250Updated: 2025-08-19

Unknown Phase

Erwinase Study in Patients With Acute Lymphoblastic Leukemia

CompletedNCT00506597

M.D. Anderson Cancer CenterLeukemia

Start: 2007-05-31End: 2012-02-29Updated: 2014-09-11

Blood2025-11-03

Increased incidence of delayed methotrexate elimination in pediatric patients with Philadelphia-chromosome positive (Ph+) or ABL-class fusion positive (ABL-Class) acute lymphoblastic leukemia treated with imatinib: Results of a retrospective cohort study by the italian association of pediatric hematology-oncology (AIEOP)

Blood2025-11-03

Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine

Frontiers in Oncology2022-12-124 citations

Comprehensive Plasma Amino Acid Analysis Following Administration of Short- and Long-Acting <i>Erwinia</i> Asparaginase (Crisantaspase) Demonstrated Significant Increase in Plasma Serine and Glycine Levels

Blood2022-11-15

A strategy to reduce cumulative anthracycline exposure in low-risk pediatric acute myeloid leukemia while maintaining favorable outcomes.

2020-07-121 citations

Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study.

2010-12-01304 citations