Eravacycline

DRUG10 trials

Conditions

CRE ColonizationCarbapenem-resistant EnterobacteralesComplicated AppendicitisComplicated Intra-abdominal InfectionsComplicated Urinary Tract InfectionsEnd Stage Renal DiseaseHematological MalignancyImmune Dysregulation Disorder

Phase 1

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

CompletedNCT02135302

Tetraphase Pharmaceuticals, IncImpaired Hepatic Function

Start: 2013-10-31End: 2014-03-31Updated: 2021-12-17

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With End Stage Renal Disease and Healthy Subjects

CompletedNCT02135276

Tetraphase Pharmaceuticals, IncEnd Stage Renal Disease

Start: 2013-12-31End: 2014-05-31Updated: 2021-12-17

Phase 2

Prospective Evaluation of Xerava Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia

RecruitingNCT05537896

West Virginia UniversityHematological Malignancy, Neutropenia

Start: 2024-02-19End: 2028-02-01Target: 55Updated: 2026-04-16

Phase 3

Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal Infections

CompletedNCT01844856

Tetraphase Pharmaceuticals, IncComplicated Intra-abdominal Infections

Start: 2013-08-31End: 2014-08-31Updated: 2022-01-11

Efficacy and Safety Study of Eravacycline Compared With Levofloxacin in Complicated Urinary Tract Infections

CompletedNCT01978938

Tetraphase Pharmaceuticals, InccUTI

Start: 2014-10-06End: 2015-08-21Updated: 2022-01-11

Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections

CompletedNCT02784704

Tetraphase Pharmaceuticals, IncComplicated Appendicitis, Complicated Intra-abdominal Infections

Start: 2016-10-13End: 2017-05-19Updated: 2022-01-06

Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Participants With Complicated Urinary Tract Infections

CompletedNCT03032510

Tetraphase Pharmaceuticals, IncComplicated Urinary Tract Infections

Start: 2017-01-31End: 2018-01-31Updated: 2022-01-06

Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation

Not yet recruitingNCT07759453

IRCCS Azienda Ospedaliero-Universitaria di BolognaCarbapenem-resistant Enterobacterales, CRE Colonization, Liver Transplant

Start: 2026-10-01End: 2029-09-30Target: 168Updated: 2026-08-12

Phase 4

Therapeutic Options for CRAB

RecruitingNCT06440304

Clinical Hospital Centre ZagrebInfections, Bacterial, Sepsis Bacterial

Start: 2025-01-30End: 2027-02-01Target: 108Updated: 2026-01-21

Unknown Phase

Efficacy and Safety of the Combination Therapy Based on Eravacycline in Immunocompromised Hosts With MDROS Infection

Not yet recruitingNCT06223100

Sichuan Provincial People's HospitalImmune Dysregulation Disorder

Start: 2024-02-01End: 2025-12-31Target: 100Updated: 2024-01-25

Clinical Infectious Diseases2018-12-12187 citations

Outcomes of high-dose levofloxacin therapy remain bound to the levofloxacin minimum inhibitory concentration in complicated urinary tract infections.

2016-11-256 citations

Assessing the Efficacy and Safety of Eravacycline vs Ertapenem in Complicated Intra-abdominal Infections in the Investigating Gram-Negative Infections Treated With Eravacycline (IGNITE 1) Trial

JAMA Surgery2016-11-16250 citations