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Epcoritamab (GEN3013)

DRUG14 trials

Sponsors

Stichting Hemato-Oncologie voor Volwassenen Nederland (Hovon), AbbVie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG, Universitaet Muenster, Fundacion Geltamo

Conditions

3L relapse/refractory large B-cell lymphoma after CAR T-cells therapy in 2nd lineB-cell Non-Hodgkin's lymphomaChronic Lymphocytic LeukemiaDiffuse Large B-Cell Lymphoma (DLBCL)Diffuse large B-cell lymphoma (DLBCL)Follicular LymphomaFollicular lymphoma (FL) grade 3BHigh-grade B-cell lymphoma (HGBL)

Phase 1

Phase 2

Combining Loncastuximab Tesirine and Epcoritamab in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)
WithdrawnCTIS2023-509861-19-00
Universitaet MuensterDiffuse large B-cell lymphoma (DLBCL), Follicular lymphoma (FL) grade 3B, High-grade B-cell lymphoma (HGBL)
Target: 104Updated: 2025-04-24
Response-adaptive to Epcoritamab In FIrst Relapse: A Phase II, response-adaptive, Open-Label, Multicenter Study to Evaluate the Efficacy of Eptoritamab in Patients with Relapse/Refractory Large B Cell Lymphoma
RecruitingCTIS2024-514440-86-00
Fundacion GeltamoRelapse/Refractory Large B Cell Lymphoma
Start: 2025-08-04Target: 80Updated: 2025-10-06
Combining Loncastuximab Tesirine and Epcoritamab in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)
RecruitingCTIS2023-509861-19-01
Universitaet MuensterDiffuse large B-cell lymphoma (DLBCL), Follicular lymphoma (FL) grade 3B, High-grade B-cell lymphoma (HGBL)
Start: 2025-09-30Target: 104Updated: 2025-12-29
HOVON 180 CLL: Prospective phase II trial of pirtobrutinib treatment (24 cycles) with 12 cycles of epcoritamab in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. ODYSSEUS study (Outcome-Driven trial for relapsed CLL/SLL combining BTK and bispecific antibodY to improve outcome)
Not yet recruitingCTIS2025-524842-89-00
Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichtingchronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)
Target: 58Updated: 2026-07-20
HOVON 168: Epcoritamab in Addition to R-Mini-CHOP Compared to R-Mini-CHOP in Elderly, Frail or Unfit Patients with Diffuse Large B-cell Lymphoma
Not yet recruitingCTIS2025-524230-25-00
Hemato-Oncologie voor Volwassenen Nederland (Hovon) StichtingDiffuse large B-cell lymphoma (DLBCL)
Target: 89Updated: 2026-09-01
BiFAST : A phase II trial evaluating fixed dose and faster ramp-up of epcoritamab with lenalidomide for 3L relapse/refractory large B-cell lymphoma after CAR T-cells therapy in 2nd line
Not yet recruitingCTIS2025-520895-24-00
LYSARC3L relapse/refractory large B-cell lymphoma after CAR T-cells therapy in 2nd line
Target: 55Updated: 2026-09-02

Phase 3

A Phase 3, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination with Rituximab and Lenalidomide (R2) compared to R2 in Subjects with Relapsed or Refractory Follicular Lymphoma (EPCORE™ FL-1)
Active, not recruitingCTIS2023-505628-67-00
AbbVie Deutschland GmbH & Co. KGRelapsed and Refractory Follicular Lymphoma
Start: 2022-10-28Target: 280Updated: 2025-12-19
A Phase 3, Randomized, Open-Label Study to Evaluate Safety and Efficacy of Epcoritamab in Combination with R-CHOP Compared to R-CHOP in Subjects with Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) (EPCORE DLBCL-2)
RecruitingCTIS2023-505277-32-00
AbbVie Deutschland GmbH & Co. KGDiffuse Large B-Cell Lymphoma (DLBCL)
Start: 2023-01-26Target: 435Updated: 2025-12-11
A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) compared to Chemoimmunotherapy in Previously Untreated Follicular Lymphoma (EPCORE™FL-2)
Active, not recruitingCTIS2023-506906-38-00
AbbVie Deutschland GmbH & Co. KGFollicular Lymphoma
Start: 2024-05-23Target: 357Updated: 2026-01-20
A Phase 3, Multicenter, Randomized, Open-Label Study of Epcoritamab Plus Lenalidomide Compared to Rituximab Plus Gemcitabine and Oxaliplatin in Participants with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
RecruitingCTIS2024-510965-41-00
AbbVie Deutschland GmbH & Co. KGRelapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)
Start: 2024-09-03Target: 116Updated: 2025-12-15