Ensitrelvir

DRUG3 trials

Sponsors

University of Oxford, Timothy Henrich, Shionogi

Conditions

COVID-19Healthy Adult Female ParticipantsLong COVIDPost Acute Sequelae of COVID-19Post-Acute COVID-19

Phase 1

A Drug-Drug Interaction Study of S-217622 With Combined Oral Contraceptives in Healthy Adult Female Participants

CompletedNCT06775730

ShionogiHealthy Adult Female Participants

Start: 2024-12-30End: 2025-04-03Updated: 2025-05-04

Phase 2

Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)

RecruitingNCT05041907

University of OxfordCOVID-19

Start: 2021-09-30End: 2027-01-01Target: 3800Updated: 2026-02-19

Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID

Active, not recruitingNCT06161688

Timothy HenrichLong COVID, Post-Acute COVID-19, Post Acute Sequelae of COVID-19

Start: 2024-04-09End: 2026-12-31Updated: 2026-04-02

Related Papers

Effects of Ensitrelvir on the Pharmacokinetics of Combined Oral Contraceptives (Ethinyl Estradiol/Drospirenone) in Healthy Adult Women: A Phase 1 Fixed-Sequence, Multiple-Dose, Drug-Drug Interaction Study.

2026-03-31

LC-MS/MS Method Validation for Quantification of Nirmatrelvir in Human Plasma.

2025-11-17

Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial.

2025-10-101 citations

Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV).

2025-01-183 citations

Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection

JAMA Internal Medicine2024-06-0782 citations

Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV).

2024-04-2410 citations

Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial.

2024-01-1518 citations

Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial.

2023-09-2852 citations

Clinical Antiviral Efficacy of Remdesivir in Coronavirus Disease 2019: An Open-Label, Randomized Controlled Adaptive Platform Trial (PLATCOV)

The Journal of Infectious Diseases2023-07-1924 citations

Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

eLife2023-02-0618 citations