Enpatoran
Sponsors
Merck Healthcare KGaA, Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany, EMD Serono Research & Development Institute, Inc., Merck
Conditions
Cutaneous Lupus ErythematosusCutaneous Lupus Erythematosus (CLE)Cutaneous Manifestations of Lupus Erythematosus With or Without Systemic DiseaseDermatomyositisHealthyImmunologyPolymyositisRenal Impairment
Phase 1
Phase 2
A Phase IIa, Randomized, Parallel, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Enpatoran in Dermatomyositis and Polymyositis Participants receiving Standard of Care
CompletedCTIS2022-501351-82-00
Start: 2023-05-23End: 2025-05-21Target: 15Updated: 2025-06-26
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging, Parallel and Adaptive Study to Evaluate the Efficacy and Safety of Enpatoran in Systemic Lupus Erythematosus and in Cutaneous Lupus Erythematosus (Subacute Cutaneous Lupus Erythematosus and/or Discoid Lupus Erythematosus) Participants Receiving Standard of Care
CompletedCTIS2024-510872-18-00
Start: 2022-05-09End: 2025-01-27Target: 127Updated: 2025-01-27
Phase 3
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease
RecruitingNCT07332481
Start: 2026-03-10End: 2029-05-24Target: 202Updated: 2026-09-11
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
RecruitingNCT07355218
Start: 2026-04-01End: 2029-05-25Target: 202Updated: 2026-09-14
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease
Not yet recruitingNCT07470957
Start: 2026-03-27End: 2029-05-24Target: 202Updated: 2026-03-13
A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)
Not yet recruitingNCT07470970
Start: 2026-03-27End: 2029-05-25Target: 202Updated: 2026-03-13
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Parallel Study to Evaluate the Efficacy and Safety of Enpatoran in Participants with Active Cutaneous Manifestations of Lupus Erythematosus With or Without Systemic Disease Receiving Standard of Care
Not yet recruitingCTIS2025-523871-44-00
Target: 16Updated: 2026-06-30
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Parallel Study to Evaluate the Efficacy and Safety of Enpatoran in Participants with Active Cutaneous Manifestations of Lupus Erythematosus With or Without Systemic Disease Receiving Standard of Care
Not yet recruitingCTIS2025-524855-30-00
Target: 15Updated: 2026-06-30
Elowen-1: A Study of Enpatoran in Cutaneous Manifestations of Lupus With or Without Systemic Disease
Active, not recruitingPACTR202608830285149
Start: 2026-05-01Target: 202Updated: 2026-09-14