Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen

DRUG3 trials

Sponsors

Azienda Ospedaliero-Universitaria Careggi, Japanese Foundation for Cancer Research, Fujian Cancer Hospital

Conditions

AbemaciclibBreast CancerBreast DiseasesBreast NeoplasmsCDK4/6 InhibitorDalpiciclibEndocrine Breast DiseasesEndocrine Therapy

Phase 2

Efficacy and Safety of Dalpiciclib Combined With Endocrine Adjuvant Therapy for Early HR +/HER2- Breast Cancer: a Multicenter, Prospective Clinical Study

RecruitingNCT07581834

Fujian Cancer HospitalBreast Diseases, Breast Neoplasms, CDK4/6 Inhibitor +3

Start: 2026-01-21End: 2032-06-30Target: 2000Updated: 2026-05-12

Phase 3

ExclUsive endocRine Therapy Or Radiation theraPy for Women Aged ≥70 Years Early Stage Breast Cancer

Active, not recruitingNCT04134598

Azienda Ospedaliero-Universitaria CareggiBreast Cancer

Start: 2021-02-08End: 2030-03-31Target: 926Updated: 2025-08-29

Adjuvant Abemaciclib for Locoregional Recurrence of HR-positive, HER2-negative Breast Cancer (JCOG2313, AURA)

RecruitingNCT07190443

Japanese Foundation for Cancer ResearchAbemaciclib, Breast Cancer, Endocrine Therapy +1

Start: 2025-02-07End: 2035-02-06Target: 290Updated: 2025-09-29

Related Papers

Abstract GS2-01: Exclusive endocrine therapy or radiation therapy in women aged 70+ years with luminal-like early breast cancer (EUROPA): preplanned interim analysis of a randomized phase 3 trial

Clinical Cancer Research2025-06-13

Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial.

2024-12-1239 citations

Toxicity of external beam accelerated partial-breast irradiation (APBI) in adjuvant therapy of early-stage breast cancer: prospective randomized study.

2024-02-034 citations

Exclusive endocrine therapy or partial breast irradiation for women aged ≥70  years with luminal A-like early stage breast cancer (NCT04134598 - EUROPA): Proof of concept of a randomized controlled trial comparing health related quality of life by patient reported outcome measures.

2020-07-2949 citations