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Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF)

DRUG5 trials

Sponsors

Gilead Sciences, University of Washington, Abbott, Emory University, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

Chronic Hepatitis BHIVHIV InfectionsHIV-1 InfectionsHuman Immunodeficiency Virus Infection

Phase 2

Study Comparing Tenofovir Disoproxil Fumarate (TDF), Emtricitabine (FTC)/TDF, and Entecavir (ETV) in the Treatment of Chronic HBV in Subjects With Decompensated Liver Disease.
CompletedNCT00298363
Gilead SciencesChronic Hepatitis B
Start: 2006-04-30End: 2011-04-30Updated: 2013-04-25
Evaluating the Pharmacokinetics, Feasibility, Acceptability, and Safety of Oral Pre-Exposure Prophylaxis for HIV Prevention During Pregnancy and Postpartum
CompletedNCT03386578
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
Start: 2018-07-03End: 2024-02-24Updated: 2025-02-19

Phase 3

Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples
CompletedNCT00557245
University of WashingtonHIV-1 Infections, HIV Infections
Start: 2008-05-31End: 2013-10-31Updated: 2019-04-19
Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)
CompletedNCT00711009
AbbottHuman Immunodeficiency Virus Infection
Start: 2008-07-31End: 2010-10-31Updated: 2012-02-14

Unknown Phase

Comprehensive HIV Prevention Package for MSM in Port Elizabeth
CompletedNCT02449733
Emory UniversityHIV
Start: 2015-05-31End: 2017-03-31Updated: 2017-07-06

Related Papers

Tenofovir Diphosphate Concentrations in Dried Blood Spots From Pregnant and Postpartum Adolescent and Young Women Receiving Daily Observed Pre-exposure Prophylaxis in Sub-Saharan Africa
Clinical Infectious Diseases2020-12-1761 citations
Quadrivalent HPV vaccine in HIV-1-infected early adolescent girls and boys in Kenya: Month 7 and 12 post vaccine immunogenicity and correlation with immune status.
2018-10-0518 citations
Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1
PLoS Pathogens2017-11-0620 citations
Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women.
2016-03-2934 citations
Changes in Glomerular Kidney Function Among HIV-1<b>–</b>Uninfected Men and Women Receiving Emtricitabine<b>–</b>Tenofovir Disoproxil Fumarate Preexposure Prophylaxis
JAMA Internal Medicine2014-12-2294 citations
Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial.
2014-10-0796 citations
Pregnancy Incidence and Outcomes Among Women Receiving Preexposure Prophylaxis for HIV Prevention
JAMA2014-07-19124 citations
Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial.
2014-07-0150 citations
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
2012-07-112548 citations
Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 prevention.
2011-10-0573 citations