Emraclidine
Sponsors
Cerevel Therapeutics LLC, AbbVie, Cerevel Therapeutics, LLC
Conditions
Alzheimer's Disease DementiaHealthyHealthy ParticipantsHealthy VolunteerHealthy VolunteersHepatic ImpairmentRenal ImpairmentSchizophrenia
Phase 1
A Multiple Dose Trial of Emraclidine in Elderly Participants and in Participants With Dementia Due to Alzheimer's Disease
CompletedNCT05644977
Start: 2022-12-02End: 2025-04-14Updated: 2025-05-02
The Effect of Food on the Pharmacokinetics (PK) of Emraclidine in Healthy Adult Participants
CompletedNCT05915546
Start: 2023-06-08End: 2023-07-26Updated: 2023-11-24
A Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics of Emraclidine
CompletedNCT05935033
Start: 2023-06-30End: 2025-02-21Updated: 2025-04-04
A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function
CompletedNCT05940402
Start: 2023-07-24End: 2024-12-19Updated: 2025-04-04
A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
CompletedNCT05965219
Start: 2023-08-15End: 2023-11-10Updated: 2024-04-02
A Study to Assess Mass Balance, Pharmacokinetics, Metabolism, and Excretion of Emraclidine in Healthy Adult Male Participants
CompletedNCT06301971
Start: 2024-03-04End: 2024-04-04Updated: 2024-05-02
A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult Participants
CompletedNCT06366243
Start: 2024-05-10End: 2024-06-20Updated: 2024-07-24
A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants
RecruitingNCT07219030
Start: 2025-10-08End: 2026-12-01Target: 52Updated: 2026-09-15
Study to Assess Adverse Events and How Oral Emraclidine Moves Through the Body of Adult Healthy Volunteers
CompletedNCT07587008
Start: 2026-05-12End: 2026-07-17Updated: 2026-08-14
Phase 2
A 52-week, Phase 2, Open-label Trial to Evaluate the Long-term Safety and Tolerability of CVL-231 in Adult Participants With Schizophrenia
CompletedCTIS2024-511441-19-00
Start: 2023-03-08End: 2025-04-22Target: 300Updated: 2025-05-22
A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia
RecruitingNCT07145918
Start: 2025-08-04End: 2028-02-01Target: 268Updated: 2026-09-15