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Emraclidine

DRUG11 trials

Sponsors

Cerevel Therapeutics LLC, AbbVie, Cerevel Therapeutics, LLC

Conditions

Alzheimer's Disease DementiaHealthyHealthy ParticipantsHealthy VolunteerHealthy VolunteersHepatic ImpairmentRenal ImpairmentSchizophrenia

Phase 1

A Multiple Dose Trial of Emraclidine in Elderly Participants and in Participants With Dementia Due to Alzheimer's Disease
CompletedNCT05644977
AbbVieAlzheimer's Disease Dementia, Healthy Participants
Start: 2022-12-02End: 2025-04-14Updated: 2025-05-02
The Effect of Food on the Pharmacokinetics (PK) of Emraclidine in Healthy Adult Participants
CompletedNCT05915546
Cerevel Therapeutics, LLCHealthy
Start: 2023-06-08End: 2023-07-26Updated: 2023-11-24
A Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics of Emraclidine
CompletedNCT05935033
AbbVieHepatic Impairment
Start: 2023-06-30End: 2025-02-21Updated: 2025-04-04
A Study to Evaluate Pharmacokinetic and Safety Trial of Emraclidine in Participants With Renal Impairment Compared With Participants With Normal Renal Function
CompletedNCT05940402
AbbVieRenal Impairment
Start: 2023-07-24End: 2024-12-19Updated: 2025-04-04
A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants
CompletedNCT05965219
Cerevel Therapeutics, LLCHealthy Volunteers
Start: 2023-08-15End: 2023-11-10Updated: 2024-04-02
A Study to Assess Mass Balance, Pharmacokinetics, Metabolism, and Excretion of Emraclidine in Healthy Adult Male Participants
CompletedNCT06301971
Cerevel Therapeutics, LLCHealthy Participants
Start: 2024-03-04End: 2024-04-04Updated: 2024-05-02
A Trial to Evaluate the Effect of Esomeprazole on the Pharmacokinetics of Emraclidine in Healthy Adult Participants
CompletedNCT06366243
Cerevel Therapeutics, LLCHealthy Participants
Start: 2024-05-10End: 2024-06-20Updated: 2024-07-24
A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants
RecruitingNCT07219030
AbbVieHealthy Volunteer
Start: 2025-10-08End: 2026-12-01Target: 52Updated: 2026-09-15
Study to Assess Adverse Events and How Oral Emraclidine Moves Through the Body of Adult Healthy Volunteers
CompletedNCT07587008
AbbVieHealthy Volunteers
Start: 2026-05-12End: 2026-07-17Updated: 2026-08-14

Phase 2