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Empliciti 300 mg powder for concentrate for solution for infusion.

DRUG5 trials

Sponsors

Regeneron Pharmaceuticals Inc., Janssen - Cilag International, University Medical Center Hamburg-Eppendorf, F. Hoffmann-La Roche AG, Universitair Medisch Centrum Groningen

Conditions

Multiple MyelomaRelapsed Refractory Multiple MyelomaRelapsed or Refractory Myelomamultiple myelomarelapsed/refractory multiple myeloma

Phase 3

AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF LINVOSELTAMAB (REGN5458; ANTI-BCMA X ANTI-CD3 BISPECIFIC ANTIBODY) VERSUS THE COMBINATION OF ELOTUZUMAB, POMALIDOMIDE, AND DEXAMETHASONE (EPd), IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (LINKER-MM3)
Active, not recruitingCTIS2022-501396-62-00
Regeneron Pharmaceuticals Inc.Relapsed Refractory Multiple Myeloma
Start: 2023-12-12Target: 188Updated: 2025-10-26
A Phase 3 Randomized Study Comparing Talquetamab in Combination with Pomalidomide (Tal-P), Talquetamab in Combination with Teclistamab (Tal-Tec), and Investigator’s Choice of Either Elotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, and Dexamethasone (PVd) in Participants with Relapsed or Refractory Myeloma who Have Received 1 to 4 Prior Lines of Therapy Including an Anti-CD38 Antibody and Lenalidomide
Active, not recruitingCTIS2022-502446-27-00
Janssen - Cilag InternationalRelapsed or Refractory Myeloma
Start: 2024-02-26Target: 453Updated: 2026-01-13
Allogeneic stem cell transplantation vs. conventional therapy as salvage therapy for relapsed / progressive patients with multiple myeloma after a first-line therapy
CompletedCTIS2024-510590-14-00
University Medical Center Hamburg-Eppendorfmultiple myeloma
Start: 2023-03-03End: 2025-01-30Target: 400Updated: 2025-02-05
HO183 CAR T: A phase III randomized trial comparing academically produced BCMA-directed CAR T-cells (ARI0002h) with standard of care regimen in patients with relapsed/refractory multiple myeloma
Not yet recruitingCTIS2025-524876-43-00
Universitair Medisch Centrum Groningenrelapsed/refractory multiple myeloma
Target: 126Updated: 2026-04-29
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Cevostamab in Combination with Pomalidomide and Dexamethasone Versus Standard of Care in Patients with Multiple Myeloma who Have Received One to Three Prior Lines of Therapy
Not yet recruitingCTIS2025-524028-23-00
F. Hoffmann-La Roche AGMultiple Myeloma
Target: 43Updated: 2026-07-08