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Elimusertib

DRUG7 trials

Sponsors

National Cancer Institute (NCI), M.D. Anderson Cancer Center

Conditions

Advanced Bile Duct CarcinomaAdvanced Breast CarcinomaAdvanced Cervical CarcinomaAdvanced Colorectal CarcinomaAdvanced Digestive System CarcinomaAdvanced Endometrial CarcinomaAdvanced Esophageal CarcinomaAdvanced Fallopian Tube Carcinoma

Phase 1

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer
Active, not recruitingNCT04491942
National Cancer Institute (NCI)Advanced Bile Duct Carcinoma, Advanced Breast Carcinoma, Advanced Cervical Carcinoma +31
Start: 2021-08-25End: 2026-06-30Target: 74Updated: 2026-04-03
Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer
Active, not recruitingNCT04514497
National Cancer Institute (NCI)Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm, Metastatic Neuroendocrine Carcinoma +9
Start: 2021-10-20End: 2026-03-04Updated: 2025-03-06
Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines
Active, not recruitingNCT04535401
National Cancer Institute (NCI)Advanced Colorectal Carcinoma, Advanced Digestive System Carcinoma, Advanced Gastric Carcinoma +11
Start: 2021-08-13End: 2025-04-29Updated: 2024-10-10
Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer
Active, not recruitingNCT04576091
National Cancer Institute (NCI)Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck +29
Start: 2022-07-06End: 2025-12-11Updated: 2024-12-13
Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors
Active, not recruitingNCT04616534
National Cancer Institute (NCI)Advanced Fallopian Tube Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma +19
Start: 2021-06-01End: 2026-05-20Updated: 2025-05-22
BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors
WithdrawnNCT05010096
M.D. Anderson Cancer CenterLocally Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm +1
Start: 2022-03-22End: 2022-03-22Updated: 2022-05-27
Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors
Active, not recruitingNCT05071209
National Cancer Institute (NCI)Recurrent Alveolar Rhabdomyosarcoma, Recurrent Ewing Sarcoma, Recurrent Lymphoma +5
Start: 2021-12-22End: 2026-03-31Updated: 2026-01-23

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