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E2609

DRUG10 trials

Sponsors

Eisai Inc., Eisai Co., Ltd.

Conditions

Alzheimer DiseaseAlzheimer's DiseaseDementia, Alzheimer TypeEarly Alzheimer's DiseaseHealthyHealthy ParticipantsHealthy SubjectsMetabolism and Elimination

Phase 1

Evaluation of the Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of E2609 in Healthy Subjects
CompletedNCT01511783
Eisai Inc.Healthy
Start: 2011-12-31End: 2012-11-30Updated: 2015-11-03
Evaluation of E2609 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (Study: E2609-A001-101 Amendment 02)
CompletedNCT01600859
Eisai Inc.Alzheimer's Disease
Start: 2012-07-31End: 2013-10-31Updated: 2016-12-30
An Study to Determine the Bioavailability of E2609 Tablets Compared to Capsules and the Effect of Food on Absorption
CompletedNCT01716897
Eisai Inc.Alzheimer's Disease
Start: 2012-10-31End: 2013-02-28Updated: 2013-05-22
An Open-label, Single Dose Study to Determine the Metabolism and Elimination of [14C]E2609 in Healthy Male Subjects
CompletedNCT01975636
Eisai Inc.Metabolism and Elimination
Start: 2013-06-30End: 2014-03-31Updated: 2016-01-08
A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil
CompletedNCT02055703
Eisai Inc.Healthy Subjects
Start: 2014-01-31End: 2014-05-31Updated: 2015-11-03
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2609 in Healthy Adult Male Japanese and White Subjects
CompletedNCT02207790
Eisai Inc.Healthy Subjects
Start: 2014-07-31End: 2014-10-31Updated: 2015-11-03
A Study to Evaluate the Effects of E2609 on QTc Interval in Healthy Subjects
CompletedNCT02222324
Eisai Inc.Healthy Subjects
Start: 2014-08-31End: 2014-12-31Updated: 2015-11-03
A Study to Evaluate the Pharmacokinetics of E2609 and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared With Healthy Subjects
CompletedNCT02859207
Eisai Inc.Early Alzheimer's Disease
Start: 2016-08-31End: 2017-01-25Updated: 2017-06-08
Study to Evaluate the Safety and Tolerability of a Once Daily Dose of 50 mg E2609 in Healthy Japanese Subjects
CompletedNCT03055962
Eisai Co., Ltd.Healthy Participants
Start: 2017-02-14End: 2017-04-11Updated: 2017-04-18

Phase 2