E2007 (perampanel)

DRUG4 trials

Sponsors

Eisai Inc.

Conditions

EpilepsyNeuralgiaRefractory Partial Seizures

Phase 2

E2007 Given as Adjunctive Therapy in Patients With Refractory Partial Seizures

CompletedNCT00144690

Eisai Inc.Epilepsy

Start: 2005-03-31End: 2007-02-28Updated: 2015-11-03

Dose-Tolerability Titration Study to Evaluate The Efficacy And Safety Of Perampanel (E2007) In Patients With Post-Herpetic Neuralgia (PHN)

CompletedNCT00592774

Eisai Inc.Neuralgia

Start: 2008-01-31End: 2009-03-31Updated: 2013-02-15

Phase 3

To Evaluate The Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures

CompletedNCT00699582

Eisai Inc.Refractory Partial Seizures

Start: 2008-05-31End: 2011-01-31Updated: 2014-07-11

Evaluating the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures

CompletedNCT00699972

Eisai Inc.Refractory Partial Seizures

Start: 2008-04-30End: 2010-10-19Updated: 2020-01-10

Related Papers

Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of focal seizures

Epilepsia2025-05-15

Time to exceed pre‐randomization monthly seizure count for perampanel in participants with primary generalized tonic–clonic seizures: A potential clinical end point

Epilepsia2022-09-1510 citations

PROVE: Retrospective, non‐interventional, Phase IV study of perampanel in real‐world clinical care of patients with epilepsy

Epilepsia Open2021-12-2326 citations

A multivariable prediction model of a major treatment response for focal-onset seizures: A post-hoc analysis of Phase III trials of perampanel.

2021-05-123 citations

Efficacy and safety of adjunctive perampanel 4 mg/d for the treatment of focal seizures: A pooled post hoc analysis of four randomized, double‐blind, phase III studies

Epilepsia2020-01-1624 citations

Efficacy and safety of adjunctive perampanel in adolescent patients with epilepsy: Post hoc analysis of six randomized studies.

2020-01-1622 citations

Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12 years) with inadequately controlled focal seizures or generalized tonic‐clonic seizures

Epilepsia2020-01-0157 citations

056 Perampanel and secondarily generalised seizures in a pooled analysis of phase III studies and their open-label extension: effect of enzyme-inducing antiepileptic drugs

Journal of Neurology Neurosurgery & Psychiatry2018-05-24

Time to prerandomization monthly seizure count in perampanel trials: A novel epilepsy endpoint.

2015-04-1533 citations

Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study.

2015-03-0559 citations

Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies.

2013-05-10202 citations

Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304.

2012-07-25384 citations