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E1224
DRUG
3 trials
Sponsors
Drugs for Neglected Diseases
Conditions
Chagas Disease
Chronic Chagas Disease, Indeterminate
Phase 1
Pharmacokinetic Drug-Drug Interaction Study
Completed
NCT03892213
Drugs for Neglected Diseases
Chagas Disease
Start: 2014-10-31
End: 2015-01-31
Updated: 2019-03-27
Phase 2
Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease
NCT01489228
Drugs for Neglected Diseases
Chronic Chagas Disease, Indeterminate
Start: 2011-06-30
End: 2013-12-31
Target: 230
Updated: 2011-12-21
BENDITA BEnznidazole New Doses Improved Treatment and Associations
NCT03378661
Drugs for Neglected Diseases
Chagas Disease
Start: 2016-11-30
End: 2018-07-27
Updated: 2017-12-20
Related Papers
Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA)
PLoS neglected tropical diseases
2025-09-22
Simulated pharmacokinetic profiles, by sex.
OPAL (Open@LaTrobe) (La Trobe University)
2025-09-22
Number of follow-up visits.
OPAL (Open@LaTrobe) (La Trobe University)
2025-09-22
Secondary pharmacokinetic parameter estimates.
OPAL (Open@LaTrobe) (La Trobe University)
2025-09-22
Outlier analysis.
OPAL (Open@LaTrobe) (La Trobe University)
2025-09-22
Flow chart of excluded patients.
OPAL (Open@LaTrobe) (La Trobe University)
2025-09-22
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials.
2025-09-09
3 citations
Early assessment of antibodies decline in Chagas patients following treatment using a serological multiplex immunoassay.
2024-12-03
2 citations
Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease
PLoS neglected tropical diseases
2022-11-21
11 citations
New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia
BMJ Open
2021-12-01
36 citations
New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial.
2021-04-06
129 citations
Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial.
2020-04-15
44 citations
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease
Antimicrobial Agents and Chemotherapy
2018-12-04
49 citations
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
2018-01-16
198 citations
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease
PLoS ONE
2017-11-27
31 citations