E. coli CD-expressing genetically modified neural stem cells

BIOLOGICAL2 trials

Conditions

Adult Anaplastic AstrocytomaAdult Anaplastic OligoastrocytomaAdult Anaplastic OligodendrogliomaAdult Brain TumorAdult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaAdult Mixed Glioma

Phase 1

A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High Grade Gliomas

CompletedNCT01172964

City of Hope Medical CenterAdult Anaplastic Astrocytoma, Adult Anaplastic Oligoastrocytoma, Adult Anaplastic Oligodendroglioma +9

Start: 2010-08-31End: 2015-02-11Updated: 2017-11-09

Genetically Modified Neural Stem Cells, Flucytosine, and Leucovorin for Treating Patients With Recurrent High-Grade Gliomas

CompletedNCT02015819

City of Hope Medical CenterAdult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma +4

Start: 2014-10-07End: 2017-10-07Updated: 2021-10-20

Journal of Clinical Oncology2024-06-016 citations

Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Survival.

2018-03-144 citations

Getting More Skin in the Game: Using Human Neural Stem Cells Transdifferentiated From Fibroblasts to Target Malignant Gliomas

Neurosurgery2017-08-011 citations

Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma

Neurosurgery2013-07-193 citations

E. coli CD-expressing genetically modified neural stem cells

Sponsors

Conditions

Phase 1

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