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DRUG3 trials

Sponsors

National Cancer Center, Japan, Cantargia AB, National Cancer Institute (NCI)

Conditions

Adenoid Cystic CarcinomaAdvanced Solid TumorsBiliary Tract CancerCarcinoma of LarynxColorectal CancerHead and Neck CancerHead and Neck Squamous Cell CarcinomaHypopharyngeal Cancer

Phase 1

A Feasibility Trial of Nivolumab With Neoadjuvant CF or DCF Therapy for Locally Advanced Esophageal Carcinoma
CompletedNCT03914443
National Cancer Center, JapanLocally Advanced Esophageal Squamous Cell Carcinoma
Start: 2019-05-07End: 2025-03-31Updated: 2025-05-31
A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors
CompletedNCT05116891
Cantargia ABAdvanced Solid Tumors, Biliary Tract Cancer, Colorectal Cancer +1
Start: 2021-09-22End: 2023-06-23Updated: 2023-07-03
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer
Not yet recruitingNCT07667400
National Cancer Institute (NCI)Adenoid Cystic Carcinoma, Carcinoma of Larynx, Head and Neck Cancer +9
Start: 2026-07-22End: 2037-10-01Target: 120Updated: 2026-07-17

Related Papers

199. THE CORRELATION BETWEEN HISTOPATHOLOGICAL RESPONSE OF NIVOLUMAB-CONTAINING NEOADJUVANT CHEMOTHERAPY AND IMMUNE CELL TYPES FOR LOCALLY ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Diseases of the Esophagus2025-08-01
271. EFFICACY OF NEOADJUVANT CF OR DCF, FLOT PLUS NIVOLUMAB FOR RESECTABLE LOCALLY ADVANCED ESOPHAGEAL SQUAMOUS CELL CARCINOMA (JCOG1804E: FRONTIER)
Diseases of the Esophagus2024-09-01
FRONTiER: A feasibility trial of nivolumab with neoadjuvant CF or DCF, FLOT therapy for locally advanced esophageal carcinoma (JCOG1804E)—Primary safety and short-term efficacy results for cohort E.
Journal of Clinical Oncology2024-01-202 citations
Safety, efficacy and biomarker data in patients with non-small cell lung cancer treated with the anti-IL1RAP antibody nadunolimab in combination with platinum doublet.
Journal of Clinical Oncology2023-06-01
FRONTiER: A feasibility trial of nivolumab with neoadjuvant CF or DCF, FLOT therapy for locally advanced esophageal carcinoma (JCOG1804E)—Short-term results for cohorts C and D.
Journal of Clinical Oncology2022-01-1922 citations
FRONTiER: A feasibility trial of nivolumab with neoadjuvant CF or DCF therapy for locally advanced esophageal carcinoma (JCOG1804E)—The short-term results of cohort A and B.
Journal of Clinical Oncology2021-01-2019 citations
A phase II, single-centre trial of neoadjuvant toripalimab plus chemotherapy in locally advanced esophageal squamous cell carcinoma
Journal of Thoracic Disease2020-11-0142 citations
Feasibility Study of Nivolumab as Neoadjuvant Chemotherapy for Locally Esophageal Carcinoma: FRONTiER (JCOG1804E)
Future Oncology2020-05-1267 citations