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Dose-escalated Radiation Therapy

RADIATION5 trials

Sponsors

Radiation Therapy Oncology Group, Emory University, Brigham and Women's Hospital, NRG Oncology, Mayo Clinic

Conditions

Ewing SarcomaGlioblastomaGlioblastoma (GBM)GliosarcomaLocally Advanced Unresectable Pancreatic Ductal AdenocarcinomaProstate CancerRound Cell Sarcoma With EWSR1-non-ETS FusionStage II Pancreatic Cancer AJCC v8

Phase 2

Spectroscopic MRI-Guided Radiation Therapy Planning in Glioblastoma
CompletedNCT03137888
Emory UniversityGlioblastoma, Gliosarcoma
Start: 2017-09-20End: 2024-09-09Updated: 2025-08-03
Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial
RecruitingNCT06835803
Brigham and Women's HospitalGlioblastoma (GBM)
Start: 2025-04-14End: 2029-03-31Target: 56Updated: 2025-09-18

Phase 3

Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer
CompletedNCT00936390
Radiation Therapy Oncology GroupProstate Cancer
Start: 2009-09-01End: 2025-09-04Updated: 2026-03-06
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer
RecruitingNCT06958328
NRG OncologyLocally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage II Pancreatic Cancer AJCC v8 +1
Start: 2025-08-21End: 2030-10-21Target: 356Updated: 2026-02-02

Unknown Phase

Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial
RecruitingNCT07188532
Mayo ClinicEwing Sarcoma, Round Cell Sarcoma With EWSR1-non-ETS Fusion
Start: 2025-11-24End: 2029-12-31Target: 141Updated: 2026-01-23

Related Papers

An Accelerated Spectroscopic MRI Metabolite Quantification Based on a Deep Learning Method for Radiation Therapy Planning in Brain Tumor Patients
Cancers2025-01-271 citations
Spectroscopic MRI-Based Biomarkers Predict Survival for Newly Diagnosed Glioblastoma in a Clinical Trial
Cancers2023-07-072 citations
Applying a Radiation Therapy Volume Analysis Pipeline to Determine the Utility of Spectroscopic MRI-Guided Adaptive Radiation Therapy for Glioblastoma
Tomography2023-05-211 citations
A multi-institutional pilot clinical trial of spectroscopic MRI-guided radiation dose escalation for newly diagnosed glioblastoma
Neuro-Oncology Advances2022-01-0140 citations
A multisite clinical trial of spectroscopic MRI-guided radiation dose escalation for newly-diagnosed glioblastomas.
Journal of Clinical Oncology2021-05-206 citations
The Longitudinal Imaging Tracker (BrICS-LIT):A Cloud Platform for Monitoring Treatment Response in Glioblastoma Patients
Tomography2020-06-0111 citations
ACTR-70. A MULTISITE CLINICAL TRIAL OF SPECTROSCOPIC MRI-GUIDED RADIATION DOSE ESCALATION IN GLIOBLASTOMA PATIENTS
Neuro-Oncology2019-11-012 citations
The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow
Tomography2019-03-0142 citations
Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging
BMC Cancer2019-02-2151 citations