Dornase Alfa

DRUG14 trials

Conditions

AtelectasisCOVID-19COVID-19 PneumoniaCoughCystic FibrosisHealthy SubjectsInflammatory ResponseIschemic Stroke

Phase 1

Pulmozyme for Sjogren's Associated Cough

WithdrawnNCT01357447

UConn HealthCough, Sjogren's Syndrome

Start: 2011-05-31End: 2012-03-31Updated: 2020-01-18

A Comparative Safety and Pharmacokinetic Study of JHL1922 and Pulmozyme® in Healthy Subjects

CompletedNCT03586076

JHL Biotech, Inc.Healthy Subjects

Start: 2018-01-26End: 2019-05-21Updated: 2020-01-07

Phase 2

Time of Ventilation and Lung Function of Ventilated Patients Under Therapy With Dornase Alfa

NCT00204685

University Hospital TuebingenLong Term Ventilation

Start: 2003-08-31End: 2006-07-31Target: 540Updated: 2006-09-14

Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.

CompletedNCT01952470

The AlfredLower Respiratory Tract Infection, Lung Transplant Infection

Start: 2013-10-31End: 2017-08-23Updated: 2019-08-28

I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients

Active, not recruitingNCT04488081

QuantumLeap Healthcare CollaborativeCOVID-19

Start: 2020-07-31End: 2030-07-31Target: 1500Updated: 2026-03-16

Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)

RecruitingNCT05203224

University of MelbourneIschemic Stroke

Start: 2022-02-18End: 2025-12-31Target: 300Updated: 2024-06-28

Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD)

Not yet recruitingNCT05880524

Ludwig-Maximilians - University of MunichInflammatory Response, Ischemic Stroke

Start: 2024-12-31End: 2026-01-31Target: 36Updated: 2024-03-19

Phase 4

A Trial of Pulmozyme Withdrawal on Exercise Tolerance in Cystic Fibrosis Subjects With Severe Lung Disease (TOPIC)

TerminatedNCT00434278

Genentech, Inc.Cystic Fibrosis

Start: 2007-03-31End: 2008-11-30Updated: 2017-05-16

A Study of Pulmozyme® (Dornase Alpha) in 3- to 5-Year-Old Patients With Cystic Fibrosis

TerminatedNCT00680316

Genentech, Inc.Cystic Fibrosis

Start: 2008-06-30End: 2009-05-31Updated: 2017-01-12

Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU)

CompletedNCT01356147

Georgetown UniversityPulmonary Infections

Start: 2011-05-31End: 2017-04-30Updated: 2018-08-07

Efficacy of Percussive Ventilation Therapy (MetaNeb ®) Compared With Mucolytic Agents for Atelectasis in the Mechanically Ventilated Pediatric Patient

CompletedNCT02168387

Duke UniversityAtelectasis

Start: 2010-12-31End: 2012-07-31Updated: 2015-03-03

Usefulness of DORNASE in COVID-19 on HFNO

TerminatedNCT05139901

University Medical Centre LjubljanaCOVID-19 Pneumonia

Start: 2021-12-01End: 2023-02-22Updated: 2023-02-23

Intrapleural Fibrinolysis and DNase versus VATS for the treatment of pleural empyema: a randomized, controlled trial

RecruitingCTIS2024-513596-40-00

Odense University HospitalPleural empyema

Start: 2024-06-28Target: 184Updated: 2024-06-26

Unknown Phase

Dornase Alfa Administered to Patients With COVID-19 (DACOVID)

CompletedNCT04387786

Feinstein Institute for Medical ResearchCOVID-19, Mechanical Ventilation

Start: 2020-03-31End: 2020-09-04Updated: 2020-11-13

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Daytime DNase-I Administration Protects Mice From Ischemic Stroke Without Inducing Bleeding or tPA-Induced Hemorrhagic Transformation, Even With Aspirin Pretreatment

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