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Docetaxel, doxorubicin, and cyclophosphamide (TAC)
DRUG
2 trials
Sponsors
BeyondSpring Pharmaceuticals Inc.
Conditions
Chemotherapy-induced Neutropenia
Phase 2
Plinabulin iv Solution in Prevention of TAC Induced Neutropenia
Completed
NCT04227990
BeyondSpring Pharmaceuticals Inc.
Chemotherapy-induced Neutropenia
Start: 2017-11-27
End: 2019-01-03
Updated: 2020-01-18
Phase 3
Plinabulin vs. Pegfilgrastim in Prevention of TAC Induced Neutropenia
NCT03294577
BeyondSpring Pharmaceuticals Inc.
Chemotherapy-induced Neutropenia
Start: 2019-10-23
End: 2025-09-25
Updated: 2021-01-15
Related Papers
A Bioinformatic Approach to the Clinical Evaluation of Linear Commitment Versus Cloud (Continuum of Low Primed UnDifferentiated) Models for Hematopoiesis Using Plinabulin Clinical Trial Data
Blood
2022-11-15
Real-world effectiveness of prophylactic granulocyte colony-stimulating factor (G-CSF) early (week 1) and late (weeks 2-3) in the cycle for the prevention of febrile neutropenia (FN) among patients (pts) with breast cancer (BC) after high FN–risk chemotherapy (chemo).
Journal of Clinical Oncology
2022-06-01
1 citations
Head-to-head comparison of the non-G-CSF small molecule single agent (SA) plinabulin with SA pegfilgrastim for the prevention of docetaxel chemotherapy (chemo)-induced neutropenia (CIN) in the protective-1 trial.
Journal of Clinical Oncology
2020-05-20
Effect of plinabulin, a novel late-clinical stage immunotherapeutic agent on the adaptive and innate immune system.
Journal of Clinical Oncology
2020-02-04
1 citations
A Randomized Phase 3 Clinical Trial of the Combination of Plinabulin (plin) + Pegfilgrastim (peg) Versus (vs) Peg Alone for Tac (docetaxel, doxorubicin, cyclophosphamide) Induced Neutropenia (cin)
Blood
2019-11-13
1 citations
Comparison of pegfilgrastim (Peg), plinabulin (Plin), and the combination for chemotherapy (Chemo) induced neutropenia (CIN) prevention: Rationale for the combination.
Journal of Clinical Oncology
2019-05-20
Plinabulin (Plin) combined with half-dose pegfilgrastim (Peg) compared with full-dose peg alone for chemotherapy- induced-neutropenia (CIN): Neutrophil, bone pain, and immunosuppressive effects.
Journal of Clinical Oncology
2019-05-20
A phase II trial with the combination of plinabulin (plin) pegfilgrastim (peg): Evaluation of the reversal of peg’s immune-suppressive potential by the addition of plin to peg.
Journal of Clinical Oncology
2019-03-10
2 citations