DNA-HIV-PT123 vaccine

BIOLOGICAL5 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

HIV Infections

Phase 1

Evaluating the Safety and Immune Response to Three HIV Vaccine Schedules in Healthy, HIV-Uninfected Adults

CompletedNCT01783977

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2013-04-30End: 2018-10-24Updated: 2021-10-15

Evaluating the Safety and Immune Response to Two HIV Vaccine Regimens in Healthy, HIV-Uninfected Adults in the United States and South Africa

WithdrawnNCT01927835

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Updated: 2021-10-15

Evaluating the Safety and Immune Response to Different Combinations of the DNA-HIV-PT123 and AIDSVAX® B/E Vaccines in Healthy, HIV-Uninfected Adults

CompletedNCT02207920

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2014-07-31End: 2015-12-31Updated: 2021-10-15

Evaluating the Safety and Immunogenicity of HIV Clade C DNA Vaccine and MF59- or AS01B-Adjuvanted Clade C Env Protein Vaccines in Various Combinations in Healthy, HIV-Uninfected Adults

CompletedNCT02915016

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2016-12-07End: 2020-02-12Updated: 2022-04-29

Safety and Immune Response to a Clade C DNA HIV Vaccine

CompletedNCT02997969

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2016-06-21End: 2018-07-11Updated: 2019-06-21

Related Papers

A polyvalent DNA prime with matched polyvalent protein/GLA-SE boost regimen elicited the most robust and broad IgG and IgG3 V1V2 binding antibody and CD4+ T cell responses among 13 HIV vaccine trials

Emerging Microbes & Infections2025-04-071 citations

Safety and Immunogenicity of a DNA Vaccine With Subtype C gp120 Protein Adjuvanted With MF59 or AS01B: A Phase 1/2a HIV-1 Vaccine Trial

JAIDS Journal of Acquired Immune Deficiency Syndromes2024-05-065 citations

Mixed Origins: HIV gp120-Specific Memory Develops from Pre-Existing Memory and Naive B Cells Following Vaccination in Humans

AIDS Research and Human Retroviruses2023-02-104 citations

Participants' characteristics and motivations to screen for HIV vaccine and monoclonal antibody trials in KwaZulu-Natal, South Africa.

2021-12-113 citations

Sequence and vector shapes vaccine induced antibody effector functions in HIV vaccine trials

PLoS Pathogens2021-11-292 citations

Phase 1 Human Immunodeficiency Virus (HIV) Vaccine Trial to Evaluate the Safety and Immunogenicity of HIV Subtype C DNA and MF59-Adjuvanted Subtype C Envelope Protein

Clinical Infectious Diseases2020-01-0135 citations

DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial

Journal of Clinical Investigation2019-09-3035 citations

Using Mobile Technology (pMOTAR) to Assess Reactogenicity: Protocol for a Pilot Randomized Controlled Trial.

2018-10-033 citations