dmLT

BIOLOGICAL6 trials

Sponsors

PATH, University of Vermont, National Institute of Allergy and Infectious Diseases (NIAID)

Conditions

DiarrheaEscherichia Coli DiarrheaEscherichia InfectionHIV InfectionsPolio

Phase 1

Live Attenuated ETEC Vaccine ACE527 With and Without dmLT Adjuvant in Adults

CompletedNCT01739231

Start: 2012-09-30End: 2014-01-31Updated: 2019-02-12

Enterotoxigenic Escherichia Coli (ETEC) ETVAX Vaccine Trial in Bangladesh

CompletedNCT02531802

PATHEscherichia Coli Diarrhea

Start: 2015-10-31End: 2017-07-29Updated: 2018-09-12

Dose Escalating Study of a Prototype CS6 Subunit Vaccine With a Modified Heat-labile Enterotoxin From Enterotoxigenic Escherichia Coli (ETEC)

CompletedNCT03404674

Start: 2018-01-16End: 2019-03-26Updated: 2021-01-06

Evaluation of Safety, Reactogenicity and Immunogenicity of Fractional-dose Inactivated Polio Vaccine (fIPV) Given Intradermally With Double Mutant Enterotoxigenic Escherichia Coli Heat Labile Toxin (dmLT) Adjuvant

CompletedNCT03922061

University of VermontPolio

Start: 2019-03-19End: 2020-06-04Updated: 2020-08-05

A Study to Assess the Safety and Immune Response to Env-C DNA and Protein Vaccines in Kenya

CompletedNCT04826094

National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections

Start: 2021-03-15End: 2024-02-13Updated: 2025-03-26

Phase 2

Efficacy Study of IM Administered CssBA+dmLT Against Moderate-severe Diarrhea in Human Infection Model With ETEC Strain B7A in Healthy Adults

Active, not recruitingNCT06692907

National Institute of Allergy and Infectious Diseases (NIAID)Escherichia Infection

Start: 2025-03-31End: 2026-08-20Updated: 2026-03-16

Related Papers

Safety and immunogenicity in humans of enterotoxigenic Escherichia coli double mutant heat-labile toxin administered intradermally.

2025-02-011 citations

Intradermal fractional-dose inactivated polio vaccine (fIPV) adjuvanted with double mutant Enterotoxigenic Escherichia coli heat labile toxin (dmLT) is well-tolerated and augments a systemic immune response to all three poliovirus serotypes in a randomized placebo-controlled trial.

2022-03-3014 citations

Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi children and infants: a double-blind, randomised, placebo-controlled phase 1/2 trial.

2019-11-1984 citations

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge

Vaccine2019-02-2273 citations

Evaluation of the safety and immunogenicity of the oral inactivated multivalent enterotoxigenic Escherichia coli vaccine ETVAX in Bangladeshi adults in a double-blind, randomized, placebo-controlled Phase I trial using electrochemiluminescence and ELISA assays for immunogenicity analyses

Vaccine2018-11-2261 citations