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Divarasib

DRUG12 trials

Sponsors

Hoffmann-La Roche, Genentech, Inc.

Conditions

CancerHealthy ParticipantsHepatic ImpairmentKRAS G12C Lung CancerMetastatic Colorectal CancerNon-Small Cell Lung CancerNon-small Cell Lung CancerSolid Tumors

Phase 1

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
RecruitingNCT04929223
Hoffmann-La RocheMetastatic Colorectal Cancer
Start: 2021-10-22End: 2030-08-31Target: 542Updated: 2026-03-31
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
RecruitingNCT05789082
Hoffmann-La RocheNon-Small Cell Lung Cancer
Start: 2023-06-20End: 2032-01-29Target: 320Updated: 2026-03-19
A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants
CompletedNCT06677957
Genentech, Inc.Healthy Participants
Start: 2024-11-06End: 2024-12-30Updated: 2025-01-03
A Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Divarasib in Healthy Participants
CompletedNCT06690138
Genentech, Inc.Healthy Participants
Start: 2024-11-15End: 2025-02-11Updated: 2025-04-15
A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function
CompletedNCT06734208
Genentech, Inc.Hepatic Impairment
Start: 2025-01-31End: 2025-11-27Updated: 2025-12-04
A Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Divarasib in Healthy Participants
CompletedNCT06835465
Genentech, Inc.Healthy Participants
Start: 2025-02-21End: 2025-05-06Updated: 2025-05-13

Phase 2

Phase 3

Related Papers

10 more papers not shown