Divarasib
Sponsors
Hoffmann-La Roche, Genentech, Inc.
Conditions
CancerHealthy ParticipantsHepatic ImpairmentKRAS G12C Lung CancerMetastatic Colorectal CancerNon-Small Cell Lung CancerNon-small Cell Lung CancerSolid Tumors
Phase 1
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
RecruitingNCT04929223
Start: 2021-10-22End: 2030-08-31Target: 542Updated: 2026-03-31
A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation
RecruitingNCT05789082
Start: 2023-06-20End: 2032-01-29Target: 320Updated: 2026-03-19
A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants
CompletedNCT06677957
Start: 2024-11-06End: 2024-12-30Updated: 2025-01-03
A Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Divarasib in Healthy Participants
CompletedNCT06690138
Start: 2024-11-15End: 2025-02-11Updated: 2025-04-15
A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function
CompletedNCT06734208
Start: 2025-01-31End: 2025-11-27Updated: 2025-12-04
A Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Divarasib in Healthy Participants
CompletedNCT06835465
Start: 2025-02-21End: 2025-05-06Updated: 2025-05-13
Phase 2
A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)
Active, not recruitingNCT03178552
Start: 2017-09-22End: 2026-10-31Target: 1000Updated: 2026-03-09
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
RecruitingNCT04302025
Start: 2020-11-06End: 2030-05-30Target: 99Updated: 2026-04-03
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
Active, not recruitingNCT04589845
Start: 2021-01-18End: 2032-09-25Target: 920Updated: 2026-04-02
Phase 3
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
RecruitingNCT05862285
Start: 2023-06-01End: 2033-03-01Target: 100Updated: 2026-03-13
A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
Active, not recruitingNCT06497556
Start: 2024-09-23End: 2029-11-30Updated: 2026-01-20
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
RecruitingNCT06793215
Start: 2025-10-24End: 2030-10-31Target: 600Updated: 2026-03-12
Related Papers
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