Divalproex

DRUG17 trials

Sponsors

Northwell Health, University Hospitals Cleveland Medical Center, University of Chicago, National Institute of Neurological Disorders and Stroke (NINDS), AstraZeneca

Conditions

Alcohol DependenceAlzheimer DiseaseBipolar DisorderBipolar I DisorderBipolar II DisorderBipolar Spectrum Disorder With Moderate-to- Severe Hypomania or Mild ManiaDementiaDementia, Alzheimer Type

Phase 2

A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder

CompletedNCT00078754

University of ChicagoIntermittent Explosive Disorder

Start: 2003-05-31End: 2008-10-31Updated: 2021-04-27

Effect of Lithium and Divalproex in Alzheimer's Disease

CompletedNCT00088387

National Institute of Neurological Disorders and Stroke (NINDS)Alzheimer Disease

Start: 2004-07-31End: 2005-03-31Target: 35Updated: 2008-03-04

Effects of Lithium and Divalproex'on Brain-Derived Neurotrophic Factor in Huntington's Disease

CompletedNCT00095355

National Institute of Neurological Disorders and Stroke (NINDS)Huntington's Disease

Start: 2004-10-31End: 2005-03-31Target: 35Updated: 2008-03-04

Phase 3

Combination Therapy for the Treatment of Bipolar Disorders

TerminatedNCT00063362

University Hospitals Cleveland Medical CenterBipolar Disorder

Start: 2002-02-28End: 2007-07-31Updated: 2016-11-07

Efficacy & Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder

CompletedNCT00107731

AstraZenecaBipolar I Disorder

Start: 2004-04-30End: 2006-10-31Target: 710Updated: 2009-03-25

Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder)

CompletedNCT00108576

VA Office of Research and DevelopmentPTSD

Start: 2003-10-31End: 2005-09-30Updated: 2015-10-21

Efficacy and Safety of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Alcohol Dependency in Patients With Bipolar Disorder

CompletedNCT00114686

AstraZenecaAlcohol Dependence, Bipolar I Disorder

Start: 2006-01-31End: 2007-04-30Target: 350Updated: 2013-01-04

Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder

CompletedNCT00194129

University Hospitals Cleveland Medical CenterBipolar Disorder

Start: 1997-11-30End: 2006-09-30Updated: 2018-02-20

Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling

CompletedNCT00221975

University Hospitals Cleveland Medical CenterBipolar Disorder

Start: 2002-07-31End: 2007-12-31Updated: 2014-12-03

Study of Divalproex Extended Release Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomania or Mild Mania

CompletedNCT00278772

Lindner Center of HOPEBipolar Spectrum Disorder With Moderate-to- Severe Hypomania or Mild Mania

Start: 2003-08-31End: 2007-12-31Updated: 2010-05-26

Phase 4

Treatment and Outcome of Early Onset Bipolar Disorder

CompletedNCT00048802

Northwell HealthBipolar Disorder

Start: 2002-08-31End: 2006-08-31Target: 40Updated: 2014-01-22

Maintenance Phase Treatment With Divalproex for Post Traumatic Stress Disorder

TerminatedNCT00203385

Tuscaloosa Research & Education Advancement CorporationPTSD

Start: 2003-05-31End: 2005-03-31Updated: 2017-04-26

A Comparison of Two Standard Therapies in the Management of Dementia With Agitation

CompletedNCT00208819

Emory UniversityAlzheimer Disease, Dementia, Dementia, Alzheimer Type +1

Start: 2003-09-30End: 2007-07-31Target: 50Updated: 2013-11-13

A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients

CompletedNCT00402324

Eli Lilly and CompanyBipolar I Disorder

Start: 2006-12-31End: 2008-02-29Updated: 2009-06-03

Sequential Multiple Assignment Treatment for Bipolar Disorder

CompletedNCT01588457

The University of Texas Health Science Center at San AntonioBipolar I Disorder, Bipolar II Disorder

Start: 2011-06-30End: 2016-12-31Updated: 2020-08-19

Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood Swings

CompletedNCT02078596

New York State Psychiatric InstituteIrritable Aggression

Start: 1997-03-31End: 2004-03-31Updated: 2017-01-04

Unknown Phase

Comparison of Immediate vs Gradual Switch to Divalproex in Adults With Intellectual Disability

CompletedNCT00347152

University of KansasEpilepsy

Start: 2006-11-30End: 2007-12-31Updated: 2008-09-12

Related Papers

Maintenance treatment with quetiapine when combined with either lithium or divalproex in bipolar I disorder: analysis of two large randomized, placebo-controlled trials.

2013-06-1222 citations

Symptoms predicting remission after divalproex augmentation with olanzapine in partially nonresponsive patients experiencing mixed bipolar I episode: a post-hoc analysis of a randomized controlled study.

2010-11-024 citations

Randomized, double-blind, placebo-controlled study of divalproex extended release loading monotherapy in ambulatory bipolar spectrum disorder patients with moderate-to-severe hypomania or mild mania.

2010-02-2314 citations

Olanzapine-divalproex combination versus divalproex monotherapy in the treatment of bipolar mixed episodes: a double-blind, placebo-controlled study.

2009-09-2241 citations

A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence.

2008-12-3057 citations