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DISC-0974

DRUG4 trials

Sponsors

Disc Medicine, Inc

Conditions

AnemiaAnemia of Chronic Kidney DiseaseChronic Kidney DiseasesHealthy VolunteerInflammatory Bowel Disease (IBD)Inflammatory Bowel Disease (IBD); AnemiaMyelodysplastic SyndromesMyelofibrosis

Phase 1

Study to Evaluate the Safety, Tolerability, PK and PD of DISC-0974 in Healthy Subjects
CompletedNCT04999527
Disc Medicine, IncHealthy Volunteer
Start: 2021-08-10End: 2022-06-30Updated: 2022-07-19
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
RecruitingNCT05320198
Disc Medicine, IncAnemia, Myelodysplastic Syndromes, Myelofibrosis +4
Start: 2022-06-06End: 2027-06-01Target: 150Updated: 2026-09-15
Study of DISC-0974 to Assess the Safety, Tolerability, PK and PD of DISC-0974 in Participants With CKD and Anemia
CompletedNCT05745883
Disc Medicine, IncAnemia of Chronic Kidney Disease, Chronic Kidney Diseases
Start: 2023-04-04End: 2026-01-16Updated: 2026-04-22

Phase 2

Study of DISC-0974-201 in Participants With IBD and Anemia
RecruitingNCT07368972
Disc Medicine, IncAnemia, Inflammatory Bowel Disease (IBD), Inflammatory Bowel Disease (IBD); Anemia
Start: 2026-02-20End: 2027-03-01Target: 21Updated: 2026-08-03

Related Papers

RALLY-MF: Initial efficacy of a phase 2 study of DISC-0974, an anti-hemojuvelin antibody, to treat anemia in myelofibrosis.
Journal of Clinical Oncology2026-05-27
ANTI-HEMOJUVELIN MONOCLONAL ANTIBODY REVERSES ANEMIA AND EXERTS DISEASE-MODIFYING EFFECTS IN A MOUSE MODEL OF INFLAMMATORY BOWEL DISEASE
Inflammatory Bowel Diseases2026-01-22
RALLY MF: A phase 2 Study of DISC-0974, an anti-hemojuvelin antibody, in patients with myelofibrosis and anemia
Blood2025-11-03
A Phase 1b Study of DISC-0974, an Anti-Hemojuvelin Antibody, in Patients with Myelofibrosis and Anemia
Blood2024-11-058 citations
Molecular and Cytokine Correlates of Anemia Response to Treatment with DISC-0974 (An Anti-Hemojuvelin Antibody) in Non-Transfusion-Dependent Patients with Myelofibrosis
Blood2024-11-052 citations
Anti-Hemojuvelin Monoclonal Antibody Alleviated Anemia Induced By Ruxolitinib Treatment in Mice
Blood2024-11-051 citations
Anti-Hemojuvelin Monoclonal Antibody Reverses Anemia and Exerts Disease-Modifying Effects in a Mouse Model of Inflammatory Bowel Disease
Blood2024-11-05
A Phase 1b Trial of DISC-0974, an Anti-Hemojuvelin Antibody, in Patients with Myelofibrosis and Anemia
Blood2023-11-026 citations
A Phase 1b Double-Blind, Placebo-Controlled Study of DISC-0974, an Anti-Hemojuvelin Antibody, in Patients with Non-Dialysis Dependent Chronic Kidney Disease and Anemia
Blood2023-11-022 citations