Direct Oral Anticoagulant (DOAC)

DRUG6 trials

Conditions

Atrial FibrillationAtrial Fibrillation (AF)Carcinoma, Non-small-Cell LungCardiovascular PreventionHip Fracture SurgeryPrevention and ControlStrokeStroke (in Patients With Atrial Fibrillation)

Early Phase 1

DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial

Not yet recruitingNCT07011095

Population Health Research InstituteAtrial Fibrillation (AF), Stroke (in Patients With Atrial Fibrillation)

Start: 2025-09-03End: 2027-06-03Target: 100Updated: 2025-06-08

Phase 2

A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer

RecruitingNCT05498428

Janssen Research & Development, LLCCarcinoma, Non-small-Cell Lung

Start: 2022-11-11End: 2028-08-18Target: 520Updated: 2026-02-13

Phase 3

Hip Fracture Surgery Arterial and Venous Thrombotic Events Prevention

Not yet recruitingNCT07228663

McMaster UniversityCardiovascular Prevention, Hip Fracture Surgery, Venous Thromboembolism (VTE)

Start: 2025-12-01End: 2027-12-01Target: 100Updated: 2025-11-14

Unknown Phase

An Observational Cross-sectional Study Evaluating the Sociodemographic and Clinical Characteristics of Patients Diagnosed With NVAF With a Risk of Stroke or Systemic Embolism, Who Are on Treatment to Adequately Control Their Coagulation and Treated in Primary Care Centres

CompletedNCT02470767

BayerAtrial Fibrillation, Prevention and Control, Stroke

Start: 2015-05-31End: 2016-03-31Updated: 2017-02-16

An Observational Cross-sectional Study Evaluating the Use of Re-sources and the Sociodemographic and Clinical Characteristics of Patients Diagnosed With Non-valvular Atrial Fibrillation With a Risk of Stroke or Systemic Embolism on Anticoagulant Therapy and Treated in Primary Care Centers

CompletedNCT02559232

BayerAtrial Fibrillation, Prevention and Control, Stroke

Start: 2015-09-30End: 2016-03-31Updated: 2017-02-16

OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial

Active, not recruitingNCT03759938

University College, LondonAtrial Fibrillation, Stroke, Acute

Start: 2019-06-18End: 2024-10-31Updated: 2024-05-14

2026-04-01

#2929 Early versus delayed anticoagulation in acute ischaemic stroke in those with chronic kidney disease: a pre-specified subgroup analysis of the OPTIMAS randomised controlled trial

Nephrology Dialysis Transplantation2025-10-01

Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST).

2025-06-237 citations

Anticoagulation Timing in Acute Stroke With Atrial Fibrillation According to Chronic Kidney Disease: The OPTIMAS Trial

Stroke2025-05-221 citations

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): statistical analysis plan for a randomised controlled trial.

2025-02-192 citations

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial.

2024-10-2334 citations

Subcutaneous amivantamab and lazertinib as first-line treatment in patients with <i>EGFR</i>-mutated, advanced non-small cell lung cancer (NSCLC): Results from the phase 2 PALOMA-2 study.

Journal of Clinical Oncology2024-06-058 citations

6MO Subcutaneous amivantamab administered every 4 weeks (Q4W) in patients with advanced solid malignancies: The phase Ib PALOMA study

ESMO Open2024-03-012 citations

Early Versus Delayed Non–Vitamin K Antagonist Oral Anticoagulant Therapy After Acute Ischemic Stroke in Atrial Fibrillation (TIMING): A Registry-Based Randomized Controlled Noninferiority Study

Circulation2022-10-03150 citations

Early initiation of rivaroxaban after reperfusion therapy for stroke patients with nonvalvular atrial fibrillation

PLoS ONE2022-04-064 citations

Optimal timing of anticoagulation after acute ischemic stroke with atrial fibrillation (OPTIMAS): Protocol for a randomized controlled trial

International Journal of Stroke2022-01-1247 citations

Protocol for LASER: A Randomized Evaluation and an Associated Registry of Early Anticoagulation With Edoxaban After Ischemic Stroke in Patients With Atrial Fibrillation

Frontiers in Neurology2021-03-316 citations