Dihydroartemisinin-piperaquine (DP)

DRUG10 trials

Conditions

MalariaMalaria (Uncomplicated)Malaria in PregnancyMalaria, AntepartumMalaria, PregnancyMalaria,FalciparumPregnancy Related

Phase 3

Chemopreventive Therapy for Malaria in Ugandan Children

CompletedNCT00948896

University of California, San FranciscoMalaria

Start: 2010-06-30End: 2014-04-30Updated: 2015-11-24

Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination

CompletedNCT03576313

London School of Hygiene and Tropical MedicineMalaria

Start: 2018-08-11End: 2021-07-31Updated: 2022-03-14

Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda

CompletedNCT04336189

Grant Dorsey, M.D, Ph.D.Malaria

Start: 2020-12-28End: 2024-07-28Updated: 2025-11-06

Modifying Immunity in Children With DihydROartemisinin-Piperaquine (MIC-DroP)

Active, not recruitingNCT04978272

Grant Dorsey, M.D, Ph.D.Malaria

Start: 2022-02-08End: 2026-08-31Updated: 2025-04-02

Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy

Active, not recruitingNCT05426434

Menzies School of Health ResearchMalaria, Malaria in Pregnancy, Pregnancy Related

Start: 2022-08-31End: 2025-12-31Target: 1172Updated: 2025-06-06

Safety of Antimalarials in the FIRst trimEster

RecruitingNCT06962319

Liverpool School of Tropical MedicineMalaria, Antepartum, Malaria, Pregnancy, Malaria (Uncomplicated)

Start: 2025-09-30End: 2029-08-31Target: 1510Updated: 2025-11-19

Phase 4

School-Based Treatment With ACT to Reduce Transmission

CompletedNCT02009215

London School of Hygiene and Tropical MedicineMalaria

Start: 2014-02-28End: 2015-04-30Updated: 2015-09-24

Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE)

CompletedNCT03178643

Duke UniversityMalaria,Falciparum

Start: 2018-01-23End: 2020-12-16Updated: 2024-04-23

Evaluation of the Implementation and Effectiveness of Intermittent Preventive Treatment for Malaria Using Dihydroartemisinin-piperaquine on Reducing Malaria Burden in School Aged Children in Tanzania

CompletedNCT04245033

National Institute for Medical Research, TanzaniaMalaria

Start: 2020-07-20End: 2021-06-28Updated: 2024-11-20

Unknown Phase

Therapeutic Efficacy Study of AL and DP in Western Kenya

CompletedNCT05060198

Kenya Medical Research InstituteMalaria,Falciparum

Start: 2016-06-17End: 2020-12-31Updated: 2021-09-29

2025-11-07

Dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda

PLoS Medicine2025-09-185 citations

Study protocol.

OPAL (Open@LaTrobe) (La Trobe University)2025-09-18

Statistical analysis plan.

OPAL (Open@LaTrobe) (La Trobe University)2025-09-18

Risk factors for non-participation in ivermectin and dihydroartemisinin-piperaquine mass drug administration for malaria control in the MASSIV trial.

2024-02-22

Implementation research of a cluster randomized trial evaluating the implementation and effectiveness of intermittent preventive treatment for malaria using dihydroartemisinin-piperaquine on reducing malaria burden in school-aged children in Tanzania: methodology, challenges, and mitigation

Malaria Journal2023-01-0619 citations

Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial

PLoS Medicine2022-10-107 citations

Mass drug administration of ivermectin and dihydroartemisinin-piperaquine against malaria in settings with high coverage of standard control interventions: a cluster-randomised controlled trial in The Gambia.

2021-12-1549 citations

Mass Drug Administration With High-Dose Ivermectin and Dihydroartemisinin-Piperaquine for Malaria Elimination in an Area of Low Transmission With High Coverage of Malaria Control Interventions: Protocol for the MASSIV Cluster Randomized Clinical Trial

JMIR Research Protocols2020-08-0324 citations

Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda: secondary outcomes of a cluster-randomized trial (START-IPT)

Malaria Journal2019-09-1819 citations

Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial): a cluster-randomised trial.

2018-04-1348 citations

Malaria burden in a birth cohort of HIV-exposed uninfected Ugandan infants living in a high malaria transmission setting.

2016-10-182 citations

Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

Malaria Journal2015-09-2424 citations

Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria in the setting of three different chemopreventive regimens

Malaria Journal2015-02-046 citations

Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial

PLoS Medicine2014-08-05112 citations

Fitness Consequences of <i>Plasmodium falciparum pfmdr1</i> Polymorphisms Inferred from <i>Ex Vivo</i> Culture of Ugandan Parasites

Antimicrobial Agents and Chemotherapy2013-06-2522 citations

Dihydroartemisinin-piperaquine (DP)

Sponsors

Conditions

Phase 3

Phase 4

Unknown Phase

Related Papers