Dihydroartemisinin-piperaquine (DHA-PPQ)

DRUG5 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), Barcelona Institute for Global Health, Jhpiego, Curtin University, Walter Reed Army Institute of Research (WRAIR)

Conditions

Acute Falciparum MalariaHIV/AIDSMalariaPregnancy RelatedUncomplicated MalariaUncomplicated P. Vivax Mono-infection

Phase 1

Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia

CompletedNCT02612545

National Institute of Allergy and Infectious Diseases (NIAID)Acute Falciparum Malaria

Start: 2015-11-20End: 2019-10-08Updated: 2019-10-10

Phase 3

Improving Maternal heAlth by Reducing Malaria in African HIV Women

CompletedNCT03671109

Barcelona Institute for Global HealthHIV/AIDS, Malaria, Pregnancy Related

Start: 2019-09-18End: 2023-06-19Updated: 2024-10-01

Phase 4

Malaria Therapeutic Efficacy Study, Rwanda

CompletedNCT04767217

JhpiegoUncomplicated Malaria

Start: 2021-06-14End: 2024-01-31Updated: 2024-02-02

Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated Malaria

Not yet recruitingNCT07403643

Curtin UniversityUncomplicated Malaria

Start: 2026-04-01End: 2026-12-01Target: 60Updated: 2026-02-12

Unknown Phase

Tafenoquine Combinations for Improved Radical Cure Efficacy of Plasmodium Vivax

Not yet recruitingNCT07533136

Walter Reed Army Institute of Research (WRAIR)Uncomplicated P. Vivax Mono-infection

Start: 2026-05-01End: 2029-05-30Target: 300Updated: 2026-04-16

Related Papers

Safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnant women with HIV from Gabon and Mozambique: a randomised, double-blind, placebo-controlled trial.

2024-01-1216 citations

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project)

BMJ Open2023-05-013 citations

Evaluation of the safety and efficacy of dihydroartemisinin–piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women: protocol of a multicentre, two-arm, randomised, placebo-controlled, superiority clinical trial (MAMAH project)

BMJ Open2021-11-0117 citations