Dexpramipexole
Sponsors
Knopp Biosciences, National Institute of Allergy and Infectious Diseases (NIAID)
Conditions
Amyotrophic Lateral SclerosisAsthmaChronic Sinusitis With Nasal Polyps and EosinophiliaEosinophilic AsthmaHealthy VolunteersHypereosinophilic Syndrome
Phase 1
Dexpramipexole SAD/MAD Study
CompletedNCT01449578
Start: 2011-11-30End: 2012-01-31Updated: 2014-11-25
Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)
CompletedNCT01511029
Start: 2012-01-31End: 2012-05-31Updated: 2014-11-25
Dexpramipexole and Cimetidine Drug Drug Interaction (DDI)
CompletedNCT01536249
Start: 2012-03-31End: 2012-04-30Updated: 2014-11-25
Dexpramipexole and Warfarin Drug Drug Interaction (DDI) Study
CompletedNCT01597310
Start: 2012-05-31End: 2012-07-31Updated: 2014-11-25
Study in Healthy Volunteers of the Bioavailability of Dexpramipexole Tablets and Food Effects
CompletedNCT01607034
Start: 2012-06-30End: 2012-07-31Updated: 2014-11-25
Phase 2
Study to Evaluate Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects With Hypereosinophilic Syndrome
NCT02101138
Start: 2014-03-14End: 2019-10-23Updated: 2017-12-07
Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia
CompletedNCT02217332
Start: 2014-08-31End: 2017-01-20Updated: 2021-05-18
Dexpramipexole Dose-Ranging Biomarker Study in Subjects With Eosinophilic Asthma
CompletedNCT04046939
Start: 2019-08-15End: 2021-03-02Updated: 2023-04-13