Dexamethasone Krka
Sponsors
Instytut Hematologii I Transfuzjologii, Medical University Of Warsaw
Conditions
Diffuse large B-cell lymphoma) and aggressive B-cell lymphomas (HGBCLDiffuse large B-cell lymphomas (DLBCLHigh-grade B-cell lymphoma) originate from mature B-cells at various stages of terminal differentiationLight chain amyloidosis (AL amyloidosis) is an incurable plasma cell neoplasm and the most common among a heterogeneous group of over 30 rare and ultra-rare diseases known as amyloidoses. In AL amyloidosis the deposition of amyloid fibrils resulting from misfolded immunoglobulin light chains leads to end-stage failure of the affected organsa 3-week treatment with sargramostim resulted in improved cognitive functiona relationship between high levels of GM-CSF in the synovial fluid and a lower risk of developing Alzheimer's diseasebased on the results of the ANDROMEDA phase III clinical trialclinical trials with opsonizing antibodies are ongoing
Phase 2
A phase II efficacy and safety study of cell-free circulating tumor DNA-guided commencement of second-line treatment in patients with DLBCL/HGBCL relapse
Not yet recruitingCTIS2024-518275-64-00
Target: 340Updated: 2025-11-24
Phase II, Multicenter Study to Assess Safety and Efficacy
of Combination of Sargramostim with D-VCd Therapy
(Daratumumab, Cyclophosphamide, Bortezomib,
Dexamethasone) in Untreated Patients with Light
Chain Amyloidosis
Active, not recruitingCTIS2024-518658-18-00
Start: 2023-07-26Target: 20Updated: 2025-09-11