Dexamethason-ratiopharm® 4 mg Tabletten
Sponsors
Celgene Corp., Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichting
Conditions
Multiple MyelomaRelapsed and refractory multiple myeloma (RRMM)Relapsed or Refractory Multiple Myeloma (RRMM)Relapsed or refractory multiple myeloma (RRMM) and newly diagnosed MM (NDMM)Smoldering Multiple Myeloma
Phase 1
An Exploratory Phase 1b/2a Multicenter, Open-Label, Novel-Novel Combination Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of CC-92480 (BMS-986348) in Novel Therapeutic Combinations in Participants with Relapsed or Refractory Multiple Myeloma
RecruitingCTIS2023-509384-25-00
Start: 2022-12-30Target: 56Updated: 2025-10-10
A Phase 1/2, Multicenter, Open-label, Study to Determine the Recommended Dose and Regimen, and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination with Standard Treatments in Subjects with Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
Active, not recruitingCTIS2023-505219-19-00
Start: 2019-09-03Target: 86Updated: 2025-09-03
A Phase 1b/2a Multicenter, Open-label, Dose Escalation Study to Determine the Maximum Tolerated Dose, Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of CC-220 as Monotherapy and in Combination with Other Treatments in Subjects with Multiple Myeloma
Active, not recruitingCTIS2024-510799-19-00
Start: 2016-08-09Target: 221Updated: 2025-08-08
Phase 2
A Phase 1/2 Multicenter, Open-label Study to Assess the Safety, Pharmacokinetics and Efficacy of CC-92480 Monotherapy and in Combination with Dexamethasone in Subjects with Relapsed and Refractory Multiple Myeloma
CompletedCTIS2023-508727-12-00
Start: 2018-04-12End: 2025-09-02Target: 46Updated: 2025-10-15
HOVON 147 MM: Carfilzomib, Lenalidomide and Dexamethasone versus Lenalidomide and Dexamethasone in High- Risk Smoldering Multiple Myeloma: A Randomized Phase 2 Study.
Active, not recruitingCTIS2024-511334-12-00
Start: 2018-11-19Target: 58Updated: 2024-09-04
Phase 3
A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib And Dexamethasone (MeziVd) Versus Pomalidomide, Bortezomib And Dexamethasone (PVd) In Subjects With Relapsed Or Refractory Multiple Myeloma (RRMM): Successor-1
RecruitingCTIS2023-509859-13-00
Start: 2022-11-09Target: 322Updated: 2025-09-25
A Phase 3, Two-Stage, Randomized, Multicenter, Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Subjects with Relapsed or Refractory Multiple Myeloma (RRMM) (EXCALIBER-RRMM)
Active, not recruitingCTIS2024-510800-35-00
Start: 2022-06-17Target: 394Updated: 2026-01-08