Desmoteplase

DRUG6 trials

Sponsors

Forest Laboratories, PAION Deutschland GmbH, H. Lundbeck A/S, Lundbeck Japan K. K.

Conditions

Acute Ischemic StrokeStrokeStroke, Acute

Phase 1

Dose Escalation of Desmoteplase in Acute Ischemic Stroke (DEDAS)

CompletedNCT00638248

PAION Deutschland GmbHStroke

Start: 2003-03-31End: 2004-10-31Updated: 2008-03-19

Phase 2

Desmoteplase in Acute Ischemic Stroke (DIAS)

CompletedNCT00638781

PAION Deutschland GmbHStroke

Start: 2001-03-31End: 2003-10-31Updated: 2008-03-19

Clinical Study of Desmoteplase in Japanese Patients With Acute Ischemic Stroke

CompletedNCT01104467

Lundbeck Japan K. K.Acute Ischemic Stroke

Start: 2010-08-31End: 2013-08-31Updated: 2021-08-31

Phase 3

Study of Desmoteplase (International Nonproprietary Name [INN]) in Acute Ischemic Stroke (DIAS-2)

CompletedNCT00111852

Forest LaboratoriesStroke, Acute

Start: 2005-04-30Updated: 2012-03-20

Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke

CompletedNCT00790920

H. Lundbeck A/SStroke

Start: 2008-12-31Updated: 2015-09-18

Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke (DIAS-4)

TerminatedNCT00856661

H. Lundbeck A/SStroke

Start: 2009-04-30Updated: 2017-03-16

Related Papers

Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke

Stroke2016-11-0257 citations

Safety and Tolerability of Desmoteplase Within 3 to 9 Hours After Symptoms Onset in Japanese Patients With Ischemic Stroke

Stroke2015-08-0718 citations

Safety and efficacy of desmoteplase given 3-9 h after ischaemic stroke in patients with occlusion or high-grade stenosis in major cerebral arteries (DIAS-3): a double-blind, randomised, placebo-controlled phase 3 trial.

2015-04-3086 citations

Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: insights from the desmoteplase in acute stroke trials.

2012-06-2642 citations

Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study.

2008-12-25389 citations