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Depsipeptide

DRUG8 trials

Sponsors

National Cancer Institute (NCI), University of Chicago, SWOG Cancer Research Network, ECOG-ACRIN Cancer Research Group, Royal Marsden NHS Foundation Trust

Conditions

Adult Anaplastic AstrocytomaAdult Anaplastic OligodendrogliomaAdult Giant Cell GlioblastomaAdult GliosarcomaAdvanced Esophageal CancersBladder CancerCancers of Non-thoracic Origin With Metastases to the Lungs or PleuraCarcinoma, Non-Small-Cell Lung

Phase 1

Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural Malignancies
CompletedNCT00037817
National Cancer Institute (NCI)Advanced Esophageal Cancers, Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura, Non-Small-Cell Lung Carcinoma +2
Start: 2002-05-17End: 2009-11-09Updated: 2019-09-30
FR901228 in Treating Patients With Recurrent High-Grade Gliomas
CompletedNCT00085540
National Cancer Institute (NCI)Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma +2
Start: 2005-01-31End: 2009-03-31Updated: 2017-01-02
Depsipeptide/Flavopiridol Infusion for Cancers of the Lungs, Esophagus, Pleura, Thymus or Mediastinum
TerminatedNCT00094978
National Cancer Institute (NCI)Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Esophageal Neoplasms +1
Start: 2004-10-25End: 2013-05-20Updated: 2019-12-12
A Phase I/II Trial of Romidepsin (Depsipeptide) and Bortezomib in Patients With Relapsed Myeloma
NCT00431990
Peter MacCallum Cancer Centre, AustraliaMultiple Myeloma
Start: 2006-11-30End: 2012-01-31Target: 40Updated: 2011-08-12

Phase 2

FR901228 in Treating Patients With Relapsed or Refractory Advanced Ovarian Epithelial Cancer
WithdrawnNCT00085527
University of ChicagoOvarian Cancer
Start: 2005-05-31End: 2005-09-30Updated: 2013-09-05
S0400, FR901228 in Treating Patients With Advanced Cancer of the Urothelium
TerminatedNCT00087295
SWOG Cancer Research NetworkBladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
Start: 2004-06-30End: 2006-04-30Updated: 2012-11-02
FR901228 in Treating Patients With Unresectable Stage III or Stage IV Malignant Melanoma
TerminatedNCT00104884
ECOG-ACRIN Cancer Research GroupMalignant Melanoma, Melanoma
Start: 2005-10-04End: 2009-03-31Updated: 2023-06-28
A Multicenter, Open-Label Continuation Trial Evaluating the Tolerability and Activity of Depsipeptide (FK228) in Patients That Have Completed a Prior Clinical Study With Depsipeptide.
NCT00299351
Royal Marsden NHS Foundation TrustPeripheral T Cell Lymphoma (PTCL)
Target: 8Updated: 2006-03-06

Related Papers

A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma.
2011-09-1260 citations
A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03.
2011-03-0392 citations