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Depemokimab

BIOLOGICAL12 trials

Sponsors

GlaxoSmithKline, Qianfoshan Hospital

Conditions

ABPAAllergic Bronchopulmonary AspergillosisAsthmaEosinophilic Granulomatosis With PolyangiitisHypereosinophilic SyndromeNasal PolypsPulmonary Disease, Chronic ObstructiveSevere Eosinophilic Asthma

Phase 1

Phase 3

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
Active, not recruitingNCT05263934
GlaxoSmithKlineEosinophilic Granulomatosis With Polyangiitis
Start: 2022-07-14End: 2026-10-27Updated: 2026-07-08
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial
RecruitingNCT05334368
GlaxoSmithKlineHypereosinophilic Syndrome
Start: 2022-09-06End: 2027-11-24Target: 109Updated: 2026-09-04
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)
RecruitingNCT06959095
GlaxoSmithKlinePulmonary Disease, Chronic Obstructive
Start: 2025-06-20End: 2029-08-20Target: 981Updated: 2025-10-08
Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
RecruitingNCT06961214
GlaxoSmithKlinePulmonary Disease, Chronic Obstructive
Start: 2025-06-23End: 2029-08-21Target: 960Updated: 2026-04-09
Depemokimab Asthma Imaging and Bronchoscopy Sub-Study
RecruitingNCT06979323
GlaxoSmithKlineAsthma
Start: 2024-07-19End: 2028-02-11Target: 150Updated: 2026-07-02
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation
RecruitingNCT07177339
GlaxoSmithKlinePulmonary Disease, Chronic Obstructive
Start: 2025-10-20End: 2029-06-08Target: 1196Updated: 2026-07-28
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
RecruitingNCT07456033
GlaxoSmithKlineAsthma
Start: 2026-03-13End: 2030-09-23Target: 456Updated: 2026-08-17
A Study of Depemokimab in Participants of 6 to 11 Years of Age
RecruitingNCT07671001
GlaxoSmithKlineAsthma
Start: 2026-06-25End: 2028-11-24Target: 34Updated: 2026-08-26

Phase 4

Unknown Phase

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