Daprodustat

DRUG14 trials

Sponsors

Kunimoto Hiroyoshi, Nippon Medical School, GlaxoSmithKline, USRC Kidney Research, Qilu Pharmaceutical Co., Ltd.

Conditions

AnaemiaAnemiaAnemia Associated With Chronic Kidney DiseaseAspergillosis, Allergic BronchopulmonaryCKD AnemiaChronic Kidney Disease (Stages 3b-5)Myelodysplastic syndromes MDS, daprodustatPeritoneal dialysis patients with renal anemia

Phase 1

Comparison of Daprodustat Formulations Produced by Two Methods of Manufacture for Bioequivalence and Dissolution in Healthy Participants

CompletedNCT04640311

GlaxoSmithKlineAnaemia

Start: 2020-12-18End: 2021-05-18Updated: 2025-04-10

Phase 2

Anemia Study in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-Blood Pressure (ASCEND-BP)

CompletedNCT03029247

GlaxoSmithKlineAnaemia

Start: 2017-07-27End: 2020-07-09Updated: 2021-06-03

Anemia Study in Chronic Kidney Disease (CKD) : Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat -Forearm Blood Flow (ASCEND-FBF)

TerminatedNCT03446612

GlaxoSmithKlineAnaemia

Start: 2019-01-10End: 2019-05-29Updated: 2024-03-27

Anemia Studies in CKD: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat- Iron (ASCEND: Fe)

CompletedNCT03457701

GlaxoSmithKlineAnaemia

Start: 2019-07-30End: 2022-07-05Updated: 2024-03-27

A single-arm trial of daprodustat for low-risk myelodysplastic syndromes

RecruitingJPRN-jRCTs031240080

Kunimoto HiroyoshiMyelodysplastic syndromes MDS, daprodustat

Start: 2024-05-28Target: 15Updated: 2026-06-29

Phase 3

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

CompletedNCT02876835

GlaxoSmithKlineAnaemia

Start: 2016-09-27End: 2021-04-19Updated: 2024-04-02

Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Dialysis (ASCEND-D)

CompletedNCT02879305

GlaxoSmithKlineAnaemia, Aspergillosis, Allergic Bronchopulmonary

Start: 2016-09-28End: 2020-11-09Updated: 2021-12-03

Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-in Incident Dialysis (ASCEND-ID)

CompletedNCT03029208

GlaxoSmithKlineAnaemia

Start: 2017-05-11End: 2020-09-24Updated: 2021-10-20

Anemia Studies in CKD: Erythropoiesis Via a Novel PHI Daprodustat - Pediatric (ASCEND-P)

CompletedNCT05682326

GlaxoSmithKlineAnaemia

Start: 2023-09-06End: 2025-03-17Updated: 2025-11-10

A Study to Evaluate Efficacy and Safety of QLG1218(Daprodustat) in Chinese Hemodialysis (HD)-Dependent Subjects With Anemia Associated With Chronic Kidney Disease (CKD)

Not yet recruitingNCT07300111

Qilu Pharmaceutical Co., Ltd.Anaemia

Start: 2025-12-31End: 2027-07-31Target: 100Updated: 2025-12-23

Phase 4

A Prospective Interventional Study Assessing the Clinical and Operational Effectiveness of Transitioning From Mircera to Daprodustat for the Treatment of Anemia in End Stage Kidney Disease

CompletedNCT05951192

USRC Kidney ResearchAnemia, Renal Anemia, Renal Insufficiency, Chronic

Start: 2023-07-01End: 2024-02-14Updated: 2024-05-24

Unknown Phase

Safety and Efficacy of Daprodustat in Peritoneal Dialysis Patients with Renal Anemia

Active, not recruitingJPRN-UMIN000045872

Nippon Medical SchoolPeritoneal dialysis patients with renal anemia

Start: 2021-09-24Target: 50Updated: 2026-06-29

REDCURE Registry for Chronic Kidney Disease (CKD) Anemia

Not yet recruitingNCT07346547

Nabiqasim Industries (Pvt) LtdCKD Anemia

Start: 2026-01-30End: 2027-05-31Target: 384Updated: 2026-01-20

Effect of Daprodustat and Epoetin Alpha on Anemia in Patients Not Undergoing Dialysis

Not yet recruitingNCT07755683

Services Hospital, LahoreAnemia Associated With Chronic Kidney Disease, Chronic Kidney Disease (Stages 3b-5)

Start: 2026-09-01End: 2027-02-28Target: 60Updated: 2026-08-10

Related Papers

Association of Different Definitions of Erythropoiesis-Stimulating Agent Hyporesponsiveness with Major Adverse Cardiovascular Events

Kidney3602025-05-071 citations

Efficacy and safety of daprodustat in patients on peritoneal dialysis in the ASCEND-D trial

Nephrology Dialysis Transplantation2024-11-21

#3807 HEART FAILURE IN ASCEND-ND AND ASCEND-D

Nephrology Dialysis Transplantation2023-06-01

#3715 THE EFFECT OF DAPRODUSTAT ON INTRAVENOUS IRON USE IN PATIENTS WITH CKD-RELATED ANAEMIA ON DIALYSIS IN THE ASCEND TRIALS

Nephrology Dialysis Transplantation2023-06-01

Comparison of Two Manufacturing Processes of Daprodustat for Bioequivalence and Dissolution in Healthy Volunteers: A Randomized Crossover Study

Clinical Pharmacology in Drug Development2023-05-011 citations

Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D)

American Journal of Nephrology2023-01-0111 citations

Analysis of on-treatment cancer safety events with daprodustat versus conventional erythropoiesis-stimulating agents—<i>post hoc</i> analyses of the ASCEND-ND and ASCEND-D trials

Nephrology Dialysis Transplantation2022-12-2410 citations

Causes of death in patients with chronic kidney disease: insights from the ASCEND-D and ASCEND-ND cardiovascular outcomes trials

European Heart Journal2022-10-018 citations

Differing approaches to analyse on-treatment cardiovascular events comparing daprodustat with darbepoetin: results from the ASCEND-ND trial

European Heart Journal2022-10-01

Efficacité du daprodustat sur le taux d’Hb et sécurité cardiovasculaire dans les études ASCEND-ND, -D, et -ID

Néphrologie & Thérapeutique2022-09-01

MO530: Daprodustat is not Associated With an Increased Risk of Cancer: Results From the ASCEND-D and ASCEND-ND Trials

Nephrology Dialysis Transplantation2022-05-012 citations

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients

JAMA Internal Medicine2022-04-0469 citations

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis

New England Journal of Medicine2021-11-05220 citations

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis

New England Journal of Medicine2021-11-05210 citations

MO559ASCEND-ND: STUDY DESIGN AND BASELINE CHARACTERISTICS

Nephrology Dialysis Transplantation2021-05-011 citations

Study design and baseline characteristics of patients on dialysis in the ASCEND-D trial

Nephrology Dialysis Transplantation2021-03-1817 citations