dalotuzumab
Sponsors
Merck Sharp & Dohme LLC, Alliance for Clinical Trials in Oncology
Conditions
Advanced Solid TumorsBreast CancerBreast NeoplasmsCarcinoma, Non-small-cell LungLung CancerMetastatic Colorectal CancerMultiple MyelomaNeoplasm
Phase 1
A Dose-finding Study of Dalotuzumab in Subjects With Advanced Solid Tumors (MK-0646-002)
CompletedNCT00635778
Start: 2006-08-07End: 2008-11-05Updated: 2018-10-09
Study of Dalotuzumab (MK-0646) in Adults With Solid Tumors (MK-0646-009)
CompletedNCT00694356
Start: 2008-08-04End: 2009-04-28Updated: 2018-08-08
Dose Escalation Trial of Dalotuzumab (MK-0646) in Advanced Solid Tumors and Multiple Myeloma (MK-0646-001)
CompletedNCT00701103
Start: 2006-01-12End: 2009-12-01Updated: 2018-08-08
The Growth Factor Signature (GFS) as an Intermediate Biomarker of Response for Development of PI3K-Pathway Inhibitors in Patients With Breast Cancer (MK-8669-050)
CompletedNCT01220570
Start: 2010-09-30End: 2012-12-31Updated: 2015-01-21
A Study of Dalotuzumab + MK-2206, Dalotuzumab + MK-0752, and Dalotuzumab + Ridaforolimus Combination Therapies in Participants With Advanced Cancer (MK-0646-027)
TerminatedNCT01243762
Start: 2010-11-22End: 2013-03-25Updated: 2018-08-16
Study of Dalotuzumab Alone and With Ridaforolimus in Pediatric Participants With Advanced Solid Tumors (MK-8669-062 AM1)
CompletedNCT01431547
Start: 2012-02-29End: 2013-09-30Updated: 2016-06-17
Phase 2
Study of Dalotuzumab (MK-0646) in Combination With Cetuximab and Irinotecan in Metastatic Colorectal Cancer (MK-0646-004)
CompletedNCT00614393
Start: 2007-12-24End: 2012-03-07Updated: 2018-08-08
A Study Evaluating Dalotuzumab (MK-0646) in Combination With Erlotinib for Participants With Non-Small Cell Lung Cancer (MK-0646-007)
CompletedNCT00654420
Start: 2008-03-19End: 2012-02-13Updated: 2018-08-08
Gemcitabine Hydrochloride and Carboplatin With or Without MK-0646 as First-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer
WithdrawnNCT00951444
Updated: 2016-07-06
A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3)
CompletedNCT01234857
Start: 2010-09-17End: 2013-10-15Updated: 2017-05-31
A Phase II Trial of Ridaforolimus and Exemestane, Compared to Ridaforolimus, Dalotuzumab and Exemestane in Participants With Breast Cancer (MK-8669-064)
CompletedNCT01605396
Start: 2012-07-04End: 2018-03-15Updated: 2019-03-25
A Trial of Dalotuzumab in Combination With Irinotecan Versus Cetuximab and Irinotecan for Participants With Metastatic Rectal Cancers (mRC) (MK-0646-025)
TerminatedNCT01609231
Start: 2012-07-06End: 2014-12-09Updated: 2020-05-04